Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3660995..3661688 Replicon chromosome
Accession NZ_CP067303
Organism Escherichia coli strain ABW_A32

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JJB23_RS17495 Protein ID WP_000415584.1
Coordinates 3661392..3661688 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JJB23_RS17490 Protein ID WP_000650107.1
Coordinates 3660995..3661390 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB23_RS17480 (3656859) 3656859..3659117 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
JJB23_RS17485 (3659255) 3659255..3660862 - 1608 WP_074520052.1 ABC transporter substrate-binding protein -
JJB23_RS17490 (3660995) 3660995..3661390 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JJB23_RS17495 (3661392) 3661392..3661688 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JJB23_RS17500 (3661893) 3661893..3662375 - 483 WP_000183505.1 GyrI-like domain-containing protein -
JJB23_RS17505 (3662428) 3662428..3662820 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JJB23_RS17510 (3662972) 3662972..3663631 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
JJB23_RS17515 (3663628) 3663628..3664977 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
JJB23_RS17520 (3665023) 3665023..3665355 - 333 WP_000917685.1 DUF2645 family protein -
JJB23_RS17525 (3665674) 3665674..3666255 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JJB23_RS17530 (3666286) 3666286..3666600 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T186052 WP_000415584.1 NZ_CP067303:c3661688-3661392 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T186052 NZ_CP089161:c1600552-1600364 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT186052 WP_000650107.1 NZ_CP067303:c3661390-3660995 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT186052 NZ_CP089161:c1600841-1600581 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References