Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2011828..2012466 Replicon chromosome
Accession NZ_CP067303
Organism Escherichia coli strain ABW_A32

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag JJB23_RS09585 Protein ID WP_001447010.1
Coordinates 2011828..2012004 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JJB23_RS09590 Protein ID WP_001270286.1
Coordinates 2012050..2012466 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB23_RS09565 (2007447) 2007447..2008622 - 1176 WP_001236265.1 BenE family transporter YdcO -
JJB23_RS09570 (2008714) 2008714..2009250 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
JJB23_RS09575 (2009323) 2009323..2011284 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JJB23_RS09580 (2011376) 2011376..2011606 - 231 WP_000494244.1 YncJ family protein -
JJB23_RS09585 (2011828) 2011828..2012004 + 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JJB23_RS09590 (2012050) 2012050..2012466 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JJB23_RS09595 (2012545) 2012545..2013951 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
JJB23_RS09600 (2014196) 2014196..2015341 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
JJB23_RS09605 (2015359) 2015359..2016372 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
JJB23_RS09610 (2016373) 2016373..2017314 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2006259..2007407 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T186037 WP_001447010.1 NZ_CP067303:2011828-2012004 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T186037 NZ_CP089159:235861-236013 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT186037 WP_001270286.1 NZ_CP067303:2012050-2012466 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT186037 NZ_CP089159:235237-235836 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References