Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3676043..3676736 Replicon chromosome
Accession NZ_CP067265
Organism Escherichia coli strain ABW_S38

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JJB13_RS17805 Protein ID WP_000415584.1
Coordinates 3676043..3676339 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JJB13_RS17810 Protein ID WP_000650107.1
Coordinates 3676341..3676736 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB13_RS17770 (3671131) 3671131..3671445 - 315 WP_000958598.1 putative quinol monooxygenase -
JJB13_RS17775 (3671476) 3671476..3672057 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JJB13_RS17780 (3672376) 3672376..3672708 + 333 WP_000917684.1 DUF2645 family protein -
JJB13_RS17785 (3672754) 3672754..3674103 - 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
JJB13_RS17790 (3674100) 3674100..3674759 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
JJB13_RS17795 (3674911) 3674911..3675303 + 393 WP_097470234.1 OB fold stress tolerance protein YgiW -
JJB13_RS17800 (3675356) 3675356..3675838 + 483 WP_000183505.1 GyrI-like domain-containing protein -
JJB13_RS17805 (3676043) 3676043..3676339 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JJB13_RS17810 (3676341) 3676341..3676736 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JJB13_RS17815 (3676869) 3676869..3678476 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
JJB13_RS17820 (3678614) 3678614..3680872 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T185994 WP_000415584.1 NZ_CP067265:3676043-3676339 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T185994 NZ_CP089142:180985-181092 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTTGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT185994 WP_000650107.1 NZ_CP067265:3676341-3676736 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT185994 NZ_CP089142:c180937-180871 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References