Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3865378..3866071 Replicon chromosome
Accession NZ_CP067250
Organism Escherichia coli strain ESBL_DR28

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JJB16_RS18350 Protein ID WP_000415584.1
Coordinates 3865775..3866071 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JJB16_RS18345 Protein ID WP_000650107.1
Coordinates 3865378..3865773 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB16_RS18335 (3861242) 3861242..3863500 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
JJB16_RS18340 (3863638) 3863638..3865245 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
JJB16_RS18345 (3865378) 3865378..3865773 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JJB16_RS18350 (3865775) 3865775..3866071 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JJB16_RS18355 (3866276) 3866276..3866758 - 483 WP_000183505.1 GyrI-like domain-containing protein -
JJB16_RS18360 (3866811) 3866811..3867203 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JJB16_RS18365 (3867355) 3867355..3868014 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
JJB16_RS18370 (3868011) 3868011..3869360 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
JJB16_RS18375 (3869406) 3869406..3869738 - 333 WP_023149630.1 DUF2645 family protein -
JJB16_RS18380 (3870057) 3870057..3870638 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JJB16_RS18385 (3870669) 3870669..3870983 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T185922 WP_000415584.1 NZ_CP067250:c3866071-3865775 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T185922 NZ_CP089063:c5218297-5218019 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGTTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT185922 WP_000650107.1 NZ_CP067250:c3865773-3865378 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT185922 NZ_CP089063:c5218007-5217702 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References