Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2206371..2207009 Replicon chromosome
Accession NZ_CP067250
Organism Escherichia coli strain ESBL_DR28

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag JJB16_RS10470 Protein ID WP_001447010.1
Coordinates 2206371..2206547 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JJB16_RS10475 Protein ID WP_001270286.1
Coordinates 2206593..2207009 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB16_RS10450 (2201990) 2201990..2203165 - 1176 WP_001236265.1 BenE family transporter YdcO -
JJB16_RS10455 (2203257) 2203257..2203793 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
JJB16_RS10460 (2203866) 2203866..2205827 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JJB16_RS10465 (2205919) 2205919..2206149 - 231 WP_000494244.1 YncJ family protein -
JJB16_RS10470 (2206371) 2206371..2206547 + 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JJB16_RS10475 (2206593) 2206593..2207009 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JJB16_RS10480 (2207088) 2207088..2208494 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
JJB16_RS10485 (2208739) 2208739..2209884 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
JJB16_RS10490 (2209902) 2209902..2210915 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
JJB16_RS10495 (2210916) 2210916..2211857 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2200802..2201950 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T185909 WP_001447010.1 NZ_CP067250:2206371-2206547 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T185909 NZ_CP089062:c144482-144204 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT185909 WP_001270286.1 NZ_CP067250:2206593-2207009 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT185909 NZ_CP089062:c144192-143887 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References