Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3809488..3810181 Replicon chromosome
Accession NZ_CP067245
Organism Escherichia coli strain OW1E2

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JJB17_RS18380 Protein ID WP_000415584.1
Coordinates 3809488..3809784 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JJB17_RS18385 Protein ID WP_000650107.1
Coordinates 3809786..3810181 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB17_RS18345 (3804576) 3804576..3804890 - 315 WP_000958598.1 putative quinol monooxygenase -
JJB17_RS18350 (3804921) 3804921..3805502 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JJB17_RS18355 (3805821) 3805821..3806153 + 333 WP_000917684.1 DUF2645 family protein -
JJB17_RS18360 (3806199) 3806199..3807548 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
JJB17_RS18365 (3807545) 3807545..3808204 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
JJB17_RS18370 (3808356) 3808356..3808748 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JJB17_RS18375 (3808801) 3808801..3809283 + 483 WP_000183505.1 GyrI-like domain-containing protein -
JJB17_RS18380 (3809488) 3809488..3809784 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JJB17_RS18385 (3809786) 3809786..3810181 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JJB17_RS18390 (3810314) 3810314..3811921 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
JJB17_RS18395 (3812059) 3812059..3814317 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T185894 WP_000415584.1 NZ_CP067245:3809488-3809784 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T185894 NZ_CP089051:562951-563334 [Acinetobacter ursingii]
ATGGTTAATCATCAATTTCAACTGAAACGCAGCTTGCTTGCCCTGTTGTTTCAGTTGGGAATGTTGCTATTGATCGGAAT
CATCTGGTTTCAGCTTTTTCCATTTTATATGTCTTTAAGTGCAATATTTTTGGCAATCATTGCTTATCTTGCGTTCTTGA
GACGTTCGAAAATGTGCTCTTTGGCTTATCTCGATCAAGATCTTTGGTCAATTCGATGGCGCAATCACAGCAAAATTGAA
CATGTGCAGCTTTATCGTGTGATAGATCACCACATTTATATAGTTCTATATTTTAAGCAAAATCGCAATTCGCAGATCAT
TTGGCGTGATCAAGTGAGTTTAAATCAATGGAAACAGCTCAAAGTCATGGCAAAACTGGTTTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT185894 WP_000650107.1 NZ_CP067245:3809786-3810181 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT185894 NZ_CP089051:562701-562958 [Acinetobacter ursingii]
ATGTCTGAAGAACTTACGCTCGAAGAGCGCAAGGTGATTTATCGTGCGCGACGCGGCCTGAAAGAAATTGATGTCTATTT
TGATCCTTATGTCCGTAATCATTACCTGAGCGCTGAACCCGCAGAAAAAGCACTTTTTGCTGAATTGGTTGATCAGGAAG
ATCCAGATTTACTGGATTGGTTTATGGAAGTATCAGAGCCACCGAAGCCAGAGCTCAAAACTTTTATTTTGAAACTCAAG
CATTACGTGCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References