Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
| Location | 2016175..2016869 | Replicon | chromosome |
| Accession | NZ_CP067245 | ||
| Organism | Escherichia coli strain OW1E2 | ||
Toxin (Protein)
| Gene name | yafO | Uniprot ID | S1EXB8 |
| Locus tag | JJB17_RS09900 | Protein ID | WP_001263493.1 |
| Coordinates | 2016175..2016573 (-) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | yafN | Uniprot ID | S1FJN6 |
| Locus tag | JJB17_RS09905 | Protein ID | WP_000554757.1 |
| Coordinates | 2016576..2016869 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| - (2011835) | 2011835..2011915 | - | 81 | NuclAT_11 | - | - |
| - (2011835) | 2011835..2011915 | - | 81 | NuclAT_11 | - | - |
| - (2011835) | 2011835..2011915 | - | 81 | NuclAT_11 | - | - |
| - (2011835) | 2011835..2011915 | - | 81 | NuclAT_11 | - | - |
| JJB17_RS09870 (2011175) | 2011175..2012419 | - | 1245 | WP_000189541.1 | esterase FrsA | - |
| JJB17_RS09875 (2012511) | 2012511..2012969 | - | 459 | WP_001291990.1 | xanthine phosphoribosyltransferase | - |
| JJB17_RS09880 (2013230) | 2013230..2014687 | + | 1458 | WP_001293003.1 | cytosol nonspecific dipeptidase | - |
| JJB17_RS09885 (2014744) | 2014744..2015265 | - | 522 | Protein_1961 | peptide chain release factor H | - |
| JJB17_RS09890 (2015264) | 2015264..2015467 | - | 204 | Protein_1962 | RtcB family protein | - |
| JJB17_RS09895 (2015713) | 2015713..2016165 | - | 453 | WP_001059847.1 | GNAT family N-acetyltransferase | - |
| JJB17_RS09900 (2016175) | 2016175..2016573 | - | 399 | WP_001263493.1 | type II toxin-antitoxin system mRNA interferase toxin YafO | Toxin |
| JJB17_RS09905 (2016576) | 2016576..2016869 | - | 294 | WP_000554757.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
| JJB17_RS09910 (2016921) | 2016921..2017976 | - | 1056 | WP_001226164.1 | DNA polymerase IV | - |
| JJB17_RS09915 (2018047) | 2018047..2018970 | - | 924 | WP_001232547.1 | putative lateral flagellar export/assembly protein LafU | - |
| JJB17_RS09920 (2018973) | 2018973..2019836 | - | 864 | WP_001169518.1 | flagellar motor stator protein MotA | - |
| JJB17_RS09925 (2019849) | 2019849..2020004 | - | 156 | Protein_1969 | sigma factor-like helix-turn-helix DNA-binding protein | - |
| JJB17_RS09930 (2020073) | 2020073..2021053 | + | 981 | WP_000019445.1 | IS5-like element ISKpn26 family transposase | - |
| JJB17_RS09935 (2021201) | 2021201..2021551 | - | 351 | Protein_1971 | REP-associated tyrosine transposase RayT | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2020073..2021053 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15472.83 Da Isoelectric Point: 8.0949
>T185888 WP_001263493.1 NZ_CP067245:c2016573-2016175 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
Download Length: 399 bp
>T185888 NZ_CP089045:113596-113883 [Acinetobacter ursingii]
ATGAAACAGTATTTCGAATGGGATGAGGCAAAGAATCGAAAGAATCAGAAAAAGCACGATGTCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCACTGAGGATCTCAATTCAGGACAGACATACCGATGGTGAAGAACGTTGGCAGACCATTGGAA
AAGTGAAAGGCGTACTAATGCTCTTAGTAGCTCATACCATCTTTGATGAAGATGACTGTGAAATCATAAGAATTATTAGT
GCAAGACAGGTAACTAAAGCAGAGCGAGATAAATATGAGCATGGTTAG
ATGAAACAGTATTTCGAATGGGATGAGGCAAAGAATCGAAAGAATCAGAAAAAGCACGATGTCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCACTGAGGATCTCAATTCAGGACAGACATACCGATGGTGAAGAACGTTGGCAGACCATTGGAA
AAGTGAAAGGCGTACTAATGCTCTTAGTAGCTCATACCATCTTTGATGAAGATGACTGTGAAATCATAAGAATTATTAGT
GCAAGACAGGTAACTAAAGCAGAGCGAGATAAATATGAGCATGGTTAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 11233.81 Da Isoelectric Point: 5.9050
>AT185888 WP_000554757.1 NZ_CP067245:c2016869-2016576 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
Download Length: 294 bp
>AT185888 NZ_CP089045:113870-114184 [Acinetobacter ursingii]
ATGAGCATGGTTAGACACTCACGCAAAGAACTGAATGAAAAATTCAGCGACAAGCAAGATGCTGAAATTGAACGCTTGCT
TGCTAAAGGCACGGTTCCTGACGATCATCTAGATCTATCAGATATGCCTGAAATTACCGACTGGAGTAATGCTGTACGCC
ACAATCAATTCTATCGTCCAGTGAAGCAACAAACATCTATTCGTTTAGATGCTGACGTACTTGCATGGTTCAAAGCACAA
GGTAAAGGTTATCAGACACGCATGAATGAAATCTTACGAGATGCCATGCTAAAAGAATTAAAAAATCATCAGTAA
ATGAGCATGGTTAGACACTCACGCAAAGAACTGAATGAAAAATTCAGCGACAAGCAAGATGCTGAAATTGAACGCTTGCT
TGCTAAAGGCACGGTTCCTGACGATCATCTAGATCTATCAGATATGCCTGAAATTACCGACTGGAGTAATGCTGTACGCC
ACAATCAATTCTATCGTCCAGTGAAGCAACAAACATCTATTCGTTTAGATGCTGACGTACTTGCATGGTTCAAAGCACAA
GGTAAAGGTTATCAGACACGCATGAATGAAATCTTACGAGATGCCATGCTAAAAGAATTAAAAAATCATCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|