185847

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 790375..791068 Replicon chromosome
Accession NZ_CP067241
Organism Escherichia coli strain P19_598

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JJB18_RS03790 Protein ID WP_000415584.1
Coordinates 790375..790671 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JJB18_RS03795 Protein ID WP_000650107.1
Coordinates 790673..791068 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB18_RS03755 (785463) 785463..785777 - 315 WP_000958598.1 putative quinol monooxygenase -
JJB18_RS03760 (785808) 785808..786389 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JJB18_RS03765 (786708) 786708..787040 + 333 WP_023149630.1 DUF2645 family protein -
JJB18_RS03770 (787086) 787086..788435 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
JJB18_RS03775 (788432) 788432..789091 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
JJB18_RS03780 (789243) 789243..789635 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JJB18_RS03785 (789688) 789688..790170 + 483 WP_000183505.1 GyrI-like domain-containing protein -
JJB18_RS03790 (790375) 790375..790671 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JJB18_RS03795 (790673) 790673..791068 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JJB18_RS03800 (791201) 791201..792808 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
JJB18_RS03805 (792946) 792946..795204 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T185847 WP_000415584.1 NZ_CP067241:790375-790671 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T185847 NZ_CP089034:3688221-3688508 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT185847 WP_000650107.1 NZ_CP067241:790673-791068 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT185847 NZ_CP089034:3688030-3688221 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References