185732

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4500606..4501387 Replicon chromosome
Accession NZ_CP067091
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ER3625

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag JJB80_RS21715 Protein ID WP_000626099.1
Coordinates 4500896..4501387 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag JJB80_RS21710 Protein ID WP_001110452.1
Coordinates 4500606..4500899 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB80_RS21675 (4496218) 4496218..4497123 + 906 WP_001268200.1 YjiK family protein -
JJB80_RS21680 (4497462) 4497462..4497920 + 459 WP_210138849.1 IS200/IS605-like element IS200F family transposase -
JJB80_RS21685 (4498129) 4498129..4498398 - 270 WP_010989096.1 hypothetical protein -
JJB80_RS21690 (4498406) 4498406..4498621 - 216 WP_001595136.1 hypothetical protein -
JJB80_RS21695 (4498644) 4498644..4498931 - 288 WP_001269916.1 transcriptional regulator RtsB -
JJB80_RS21700 (4498928) 4498928..4499803 - 876 WP_000921675.1 AraC family transcriptional regulator -
JJB80_RS21705 (4500068) 4500068..4500289 - 222 WP_001576552.1 hypothetical protein -
JJB80_RS21710 (4500606) 4500606..4500899 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
JJB80_RS21715 (4500896) 4500896..4501387 + 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
JJB80_RS21720 (4501635) 4501635..4502387 - 753 WP_210138850.1 phosphatase PAP2 family protein -
JJB80_RS23900 (4502490) 4502490..4502564 - 75 Protein_4248 porin family protein -
JJB80_RS21725 (4503596) 4503596..4503973 - 378 WP_000916345.1 EthD family reductase -
JJB80_RS21730 (4504045) 4504045..4504377 + 333 WP_001165471.1 MerR family transcriptional regulator -
JJB80_RS21735 (4504468) 4504468..4504545 + 78 Protein_4251 helix-turn-helix domain-containing protein -
JJB80_RS21745 (4504816) 4504816..4505391 - 576 WP_001188509.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4497462..4497920 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T185732 WP_000626099.1 NZ_CP067091:4500896-4501387 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T185732 NZ_CP089012:c4467918-4467385 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT185732 WP_001110452.1 NZ_CP067091:4500606-4500899 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT185732 NZ_CP089012:c4468195-4467929 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References