Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2252561..2253095 Replicon chromosome
Accession NZ_CP067071
Organism Rhizobium sp. AB2/73

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag I8E17_RS11160 Protein ID WP_083258170.1
Coordinates 2252561..2252827 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1E4YBJ2
Locus tag I8E17_RS11165 Protein ID WP_069612752.1
Coordinates 2252835..2253095 (-) Length 87 a.a.

Genomic Context

I8E17_RS11145I8E17_RS11150I8E17_RS11155I8E17_RS11140I8E17_RS11160I8E17_RS11165I8E17_RS11170I8E17_RS11175I8E17_RS11180I8E17_RS11185I8E17_RS11190I8E17_RS11195I8E17_RS11200
Location: 2248835..2250073 (1239 bp)
Type: Others
Protein ID: WP_069612749.1
Location: 2250070..2251377 (1308 bp)
Type: Others
Protein ID: WP_069612750.1
Location: 2251425..2252564 (1140 bp)
Type: Others
Protein ID: WP_069612751.1
Location: 2248286..2248621 (336 bp)
Type: Others
Protein ID: WP_069612748.1
Location: 2252561..2252827 (267 bp)
Type: Toxin
Protein ID: WP_083258170.1
Location: 2252835..2253095 (261 bp)
Type: Antitoxin
Protein ID: WP_069612752.1
Location: 2253161..2253901 (741 bp)
Type: Others
Protein ID: WP_069612753.1
Location: 2253904..2254260 (357 bp)
Type: Others
Protein ID: WP_069612754.1
Location: 2254257..2254757 (501 bp)
Type: Others
Protein ID: WP_069612755.1
Location: 2254765..2255127 (363 bp)
Type: Others
Protein ID: WP_069612756.1
Location: 2255356..2255853 (498 bp)
Type: Others
Protein ID: WP_069612757.1
Location: 2255855..2256778 (924 bp)
Type: Others
Protein ID: WP_069612758.1
Location: 2256895..2257602 (708 bp)
Type: Others
Protein ID: WP_069612759.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I8E17_RS11140 (I8E17_11125)2248286..2248621-336WP_069612748.1hypothetical protein-
I8E17_RS11145 (I8E17_11130)2248835..2250073+1239WP_069612749.1urate hydroxylase PuuD-
I8E17_RS11150 (I8E17_11135)2250070..2251377+1308WP_069612750.1guanine deaminase-
I8E17_RS11155 (I8E17_11140)2251425..2252564+1140WP_069612751.1alpha-hydroxy acid oxidase-
I8E17_RS11160 (I8E17_11145)2252561..2252827-267WP_083258170.1Txe/YoeB family addiction module toxinToxin
I8E17_RS11165 (I8E17_11150)2252835..2253095-261WP_069612752.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
I8E17_RS11170 (I8E17_11155)2253161..2253901-741WP_069612753.1metallophosphoesterase family protein-
I8E17_RS11175 (I8E17_11160)2253904..2254260-357WP_069612754.1hydroxyisourate hydrolase-
I8E17_RS11180 (I8E17_11165)2254257..2254757-501WP_069612755.1ureidoglycolate lyase-
I8E17_RS11185 (I8E17_11170)2254765..2255127-363WP_069612756.1DUF86 domain-containing protein-
I8E17_RS11190 (I8E17_11175)2255356..2255853-498WP_069612757.12-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase-
I8E17_RS11195 (I8E17_11180)2255855..2256778-924WP_069612758.1allantoinase PuuE-
I8E17_RS11200 (I8E17_11185)2256895..2257602-708WP_069612759.1DUF1045 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10807.46 Da        Isoelectric Point: 9.9059

>T185696 WP_083258170.1 NZ_CP067071:c2252827-2252561 [Rhizobium sp. AB2/73]
MLLAWHAHAWEDYLYWRERDRKIAVRINELLRDALRHPFEGLGKPEALRNQLKGQWSRRITQEHRLIYKVEGEGDRQILI
VLQCRFHY

Download         Length: 267 bp

>T185696 NZ_CP088997:2519832-2521154 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9557.92 Da        Isoelectric Point: 4.5084

>AT185696 WP_069612752.1 NZ_CP067071:c2253095-2252835 [Rhizobium sp. AB2/73]
MRTVMFSAARNELASLLDEVVQDRVAVEIVRRDKPSAILIDKEEYEGIIETLHVLSTPANAARLMEAITDANEGKNLVSH
DLIDPK

Download         Length: 261 bp

>AT185696 NZ_CP088997:2519566-2519832 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1E4YBJ2

References