Detailed information of TA system TA185646

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 3736134..3736961
• Replicon: chromosome
• Accession: NZ_CP067057
• Organism: Rahnella aceris strain ZF458

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: JHW33_RS17035
• Protein ID: WP_037033823.1
• Coordinates: 3736134..3736610 (-)
• Length: 159 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: A0A0H3F4N7
• Locus tag: JHW33_RS17040
• Protein ID: WP_013573435.1
• Coordinates: 3736617..3736961 (-)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JHW33_RS17005	3731208..3732653	+	1446	WP_200223571.1	alpha/beta hydrolase	-
JHW33_RS17010	3732724..3733182	+	459	WP_013573431.1	MarR family transcriptional regulator	-
JHW33_RS17015	3733317..3733739	+	423	WP_013573432.1	organic hydroperoxide resistance protein	-
JHW33_RS17020	3734011..3735690	+	1680	WP_037033825.1	kdo(2)-lipid A phosphoethanolamine 7''-transferase	-
JHW33_RS17035	3736134..3736610	-	477	WP_037033823.1	type II toxin-antitoxin system YhaV family toxin	Toxin
JHW33_RS17040	3736617..3736961	-	345	WP_013573435.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
JHW33_RS17045	3737043..3737372	-	330	WP_037033821.1	type II toxin-antitoxin system RelE/ParE family toxin	-
JHW33_RS17050	3737341..3737577	-	237	WP_037033819.1	ParD-like family protein	-
JHW33_RS17055	3737789..3739168	-	1380	WP_200223572.1	MmgE/PrpD family protein	-
JHW33_RS17060	3739188..3739970	-	783	WP_200223573.1	ABC transporter ATP-binding protein	-
JHW33_RS17065	3739970..3740836	-	867	WP_134706483.1	ABC transporter ATP-binding protein	-
JHW33_RS17070	3740829..3741764	-	936	WP_112197519.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (13-148)

Antitoxin

• SpoVT-AbrB domain (15-53)

Sequences

Toxin

Protein

• Length: 159 a.a.
• Molecular weight: 18516.32 Da
• Isoelectric Point: 9.9550

>T185646 WP_037033823.1 NZ_CP067057:c3736610-3736134 [Rahnella aceris]
MHNQAMEINGWTLLAHPLILQQIQALTDQVVLLRRKDPAGYKSKNATKRLAAINKLMFDVIPQDPARVEFRQGDTLGGEF
SHWFRAKFFQQYRLFFRYNLKSRIIIYAWVNDDKELRAYESKTDAYRMFRKMLKSGEPPDNWQALCEASGKVAAEEFP

Nucleotide

• Length: 477 bp

>T185646 NZ_CP088985:c963088-962678 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 12701.48 Da
• Isoelectric Point: 4.3324

>AT185646 WP_013573435.1 NZ_CP067057:c3736961-3736617 [Rahnella aceris]
MSASALWGIKFEAESKVTRRFQTTIPATIRKALNLTENDRIQYKILPDGQVVISRQLEEAEDPVISAFLGFVAKDMLNNP
ENMQPVTLSLHEKINVLTAGMAIDLESPLSDDDE

Nucleotide

• Length: 345 bp

>AT185646 NZ_CP088985:c963335-963069 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3F4N7