Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-YefM
Location 1661786..1662306 Replicon chromosome
Accession NZ_CP067027
Organism Agrobacterium fabrum strain GV2260

Toxin (Protein)


Gene name yoeB Uniprot ID A9CID9
Locus tag EML4058_RS08290 Protein ID WP_010972002.1
Coordinates 1661786..1662055 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q7CY23
Locus tag EML4058_RS08295 Protein ID WP_010972003.1
Coordinates 1662052..1662306 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EML4058_RS08270 1656817..1658511 - 1695 WP_010971998.1 iron ABC transporter permease -
EML4058_RS08275 1658521..1659504 - 984 WP_010971999.1 ABC transporter substrate-binding protein -
EML4058_RS08280 1659813..1661057 - 1245 WP_010972000.1 PLP-dependent aminotransferase family protein -
EML4058_RS08285 1661332..1661781 + 450 WP_010972001.1 RbsD/FucU family protein -
EML4058_RS08290 1661786..1662055 - 270 WP_010972002.1 Txe/YoeB family addiction module toxin Toxin
EML4058_RS08295 1662052..1662306 - 255 WP_010972003.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
EML4058_RS08300 1662445..1663464 - 1020 WP_010972004.1 ketol-acid reductoisomerase -
EML4058_RS08305 1663512..1664165 - 654 WP_006311841.1 TetR/AcrR family transcriptional regulator -
EML4058_RS08310 1664565..1665470 - 906 WP_010972005.1 AraC family transcriptional regulator -
EML4058_RS08315 1665660..1666706 + 1047 WP_006311839.1 NAD(P)-dependent alcohol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10612.09 Da        Isoelectric Point: 9.8742

>T185600 WP_010972002.1 NZ_CP067027:c1662055-1661786 [Agrobacterium fabrum]
MKLVWTLSSWDDYEFWQRTDARMVEKINDLIRNAKRTPFAGLGKPEPLKGDMAGYWSRRITAEHRFVYRVSGSGSEQRLE
VIQCRFHYQ

Download         Length: 270 bp

>T185600 NZ_CP088935:c2827967-2827764 [Thauera sp. WB-2]
ATGTACCTGCTCGACACCAACATCATCAGCGAGCTGCGAAAAGGTGGGCGTGCCAATCCGGGCGTGACCGCCTTTTTCGC
CACCCTGGCCGCGGAGGACATCTATCTGTCGGTCCTGACAATCGGTGAGATTCGCCGGGGCCTAGCAGCCTGTCGGACTA
CCCCCTGTAAAATGCCGCATCGCCCCCGGATCCTGAGAGCATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9577.70 Da        Isoelectric Point: 4.6749

>AT185600 WP_010972003.1 NZ_CP067027:c1662306-1662052 [Agrobacterium fabrum]
MANVRFTEFRQNFATHFDRVLETRAPLLVTRQGKEAVVVLAEGEYESMQETLHLLSNPANASRLRASMGELERGDTIERD
PTEE

Download         Length: 255 bp

>AT185600 NZ_CP088935:c2828179-2827967 [Thauera sp. WB-2]
ATGGCGACTAATCTTGTCGTTCGTAACATCGAGCCTTCGGTCGCGCAGGCTTTGAAAGAGGCTGCGGCGCGGCACGGTCG
AAGCGCTGAGGCGGAGCATCGGGAAATCCTGCGGGCAGCGCTTGCGCGACCTGCGCGGCGGACCTTCAAAGACGTTCTGG
CCAGCATGCCGGACGTGGGTGCCGATGAAGACTTCAACCTCAGGCAGGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6N90

Antitoxin

Source ID Structure
AlphaFold DB Q7CY23

References