185437

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4802857..4803632 Replicon chromosome
Accession NZ_CP066915
Organism Klebsiella pneumoniae strain XHKPN391

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag JG797_RS23735 Protein ID WP_004150910.1
Coordinates 4802857..4803342 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag JG797_RS23740 Protein ID WP_004150912.1
Coordinates 4803339..4803632 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG797_RS23710 (4798026) 4798026..4799393 - 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -
JG797_RS23715 (4799386) 4799386..4799769 - 384 WP_004150906.1 hypothetical protein -
JG797_RS23720 (4799769) 4799769..4800641 - 873 WP_004188557.1 ParA family protein -
JG797_RS23725 (4801247) 4801247..4801463 - 217 Protein_4658 transposase -
JG797_RS23730 (4801560) 4801560..4802153 - 594 WP_004188553.1 hypothetical protein -
JG797_RS23735 (4802857) 4802857..4803342 - 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
JG797_RS23740 (4803339) 4803339..4803632 - 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
JG797_RS23745 (4804277) 4804277..4805653 + 1377 WP_004217775.1 cystathionine beta-synthase -
JG797_RS23750 (4805664) 4805664..4806812 + 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
JG797_RS23755 (4806813) 4806813..4807724 - 912 WP_004188550.1 LysR family transcriptional regulator -
JG797_RS23760 (4807822) 4807822..4808424 + 603 WP_062954968.1 short chain dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 4745837..4803883 58046
flank IS/Tn - - 4801311..4801463 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T185437 WP_004150910.1 NZ_CP066915:c4803342-4802857 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T185437 NZ_CP088218:1983571-1983756 [Staphylococcus sp. HL28]
ATGAGCTTGCATTTTACAATTCTTTTTTGGCTTTCACTTATATTTATCGTAGCTGGTGCAATTATTCTAGCTATCATGCT
TAAAACTAAAAAAGAATCTAAAAAGGAATCTTATCTTGGTTTCACCATTGTATTCTTCATTTTTGGATTAGCGATGTTAA
TTTATACATTGTTATTTGGACTCTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT185437 WP_004150912.1 NZ_CP066915:c4803632-4803339 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT185437 NZ_CP088218:1983294-1983551 [Staphylococcus sp. HL28]
ATGAAACTATACATTATACATGCAATCAATATTATTATAACGATATTATTTATTATTTTTAATGTAATTATTACTTATAA
TACAAACCTAGACGATACCTTATGGTTGGTGCCTGGATTAATTGTATGCGGTTTGATTATGATGATTAGCTTTGGTATAG
CTATATCCAATAAGGACTTGTTAAGTGAAGTTCTTTTCTTTATTAATATTATTCTTACACTGTATTACATTTATCCAATT
TTTTATGATTTTCTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References