185256

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 177602..178125 Replicon chromosome
Accession NZ_CP066885
Organism Staphylococcus pseudintermedius strain HSP079

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7T7NYR3
Locus tag JGZ27_RS00780 Protein ID WP_065520308.1
Coordinates 177859..178125 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A3D8YKM0
Locus tag JGZ27_RS00775 Protein ID WP_014612814.1
Coordinates 177602..177859 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGZ27_RS00755 172931..173113 - 183 WP_096536006.1 hypothetical protein -
JGZ27_RS00760 173641..174447 + 807 WP_200264976.1 arylamine N-acetyltransferase -
JGZ27_RS00765 174741..175235 - 495 WP_015729749.1 membrane protein -
JGZ27_RS00770 175495..177408 + 1914 WP_200264977.1 triacylglycerol lipase -
JGZ27_RS00775 177602..177859 + 258 WP_014612814.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JGZ27_RS00780 177859..178125 + 267 WP_065520308.1 Txe/YoeB family addiction module toxin Toxin
JGZ27_RS00785 178476..178577 - 102 WP_200264978.1 DUF2648 domain-containing protein -
JGZ27_RS00790 178591..180087 - 1497 WP_200264979.1 malate dehydrogenase (quinone) -
JGZ27_RS00795 180844..180945 + 102 Protein_157 KxYKxGKxW signal peptide domain-containing protein -
JGZ27_RS00800 182394..182840 - 447 WP_200265524.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10532.09 Da        Isoelectric Point: 10.1217

>T185256 WP_065520308.1 NZ_CP066885:177859-178125 [Staphylococcus pseudintermedius]
MGNYSVLIKNSAKNDLKKIKKSLLKEQFSKIIEVLKINPYEASQSFEMLQPKHSARYSRRLNHQHRVVYTVDDEKREVYI
FSAWSHYE

Download         Length: 267 bp

>T185256 NZ_CP088125:26702-27007 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCTGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9866.87 Da        Isoelectric Point: 4.1100

>AT185256 WP_014612814.1 NZ_CP066885:177602-177859 [Staphylococcus pseudintermedius]
MIIKTPTNARKEFYELLKQVNDNHEPIIISGSKSENNAVIVSQEDWDSIQETLFLEYTGTMDKVRAREKDDSGYTNIDDI
DWDNL

Download         Length: 258 bp

>AT185256 NZ_CP088125:26482-26700 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T7NYR3

Antitoxin

Source ID Structure
AlphaFold DB A0A3D8YKM0

References