185253

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 177608..178131 Replicon chromosome
Accession NZ_CP066884
Organism Staphylococcus pseudintermedius strain HSP080

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7T7NYR3
Locus tag JGZ15_RS00780 Protein ID WP_065520308.1
Coordinates 177865..178131 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A3D8YKM0
Locus tag JGZ15_RS00775 Protein ID WP_014612814.1
Coordinates 177608..177865 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGZ15_RS00755 172941..173123 - 183 WP_096536006.1 hypothetical protein -
JGZ15_RS00760 173650..174459 + 810 WP_200360893.1 arylamine N-acetyltransferase -
JGZ15_RS00765 174753..175247 - 495 WP_015729749.1 membrane protein -
JGZ15_RS00770 175507..177414 + 1908 WP_200360894.1 triacylglycerol lipase -
JGZ15_RS00775 177608..177865 + 258 WP_014612814.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JGZ15_RS00780 177865..178131 + 267 WP_065520308.1 Txe/YoeB family addiction module toxin Toxin
JGZ15_RS00785 178482..178584 - 103 Protein_155 DUF2648 domain-containing protein -
JGZ15_RS00790 178598..180094 - 1497 WP_200360895.1 malate dehydrogenase (quinone) -
JGZ15_RS00795 180851..182482 + 1632 WP_200360896.1 KxYKxGKxW signal peptide domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10532.09 Da        Isoelectric Point: 10.1217

>T185253 WP_065520308.1 NZ_CP066884:177865-178131 [Staphylococcus pseudintermedius]
MGNYSVLIKNSAKNDLKKIKKSLLKEQFSKIIEVLKINPYEASQSFEMLQPKHSARYSRRLNHQHRVVYTVDDEKREVYI
FSAWSHYE

Download         Length: 267 bp

>T185253 NZ_CP088124:21863-22279 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9866.87 Da        Isoelectric Point: 4.1100

>AT185253 WP_014612814.1 NZ_CP066884:177608-177865 [Staphylococcus pseudintermedius]
MIIKTPTNARKEFYELLKQVNDNHEPIIISGSKSENNAVIVSQEDWDSIQETLFLEYTGTMDKVRAREKDDSGYTNIDDI
DWDNL

Download         Length: 258 bp

>AT185253 NZ_CP088124:21636-21866 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T7NYR3

Antitoxin

Source ID Structure
AlphaFold DB A0A3D8YKM0

References