Detailed information of TA system TA185230

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 364240..364778
• Replicon: chromosome
• Accession: NZ_CP066851
• Organism: Salmonella enterica subsp. enterica serovar Heidelberg strain SH-2813-Parental

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: A0A8E7RBX8
• Locus tag: JIG31_RS01660
• Protein ID: WP_001682450.1
• Coordinates: 364503..364778 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: A0A7U1KUN1
• Locus tag: JIG31_RS01655
• Protein ID: WP_000729714.1
• Coordinates: 364240..364500 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JIG31_RS01640 (359951)	359951..361504	+	1554	WP_000013007.1	TROVE domain-containing protein	-
JIG31_RS01645 (361852)	361852..363066	+	1215	WP_001105530.1	RNA-splicing ligase RtcB	-
JIG31_RS01650 (363070)	363070..364131	+	1062	WP_000101032.1	RNA 3'-terminal phosphate cyclase	-
JIG31_RS01655 (364240)	364240..364500	+	261	WP_000729714.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JIG31_RS01660 (364503)	364503..364778	+	276	WP_001682450.1	type II toxin-antitoxin system YafQ family toxin	Toxin
JIG31_RS01665 (364866)	364866..367571	-	2706	WP_000907043.1	HTH-type transcriptional regulator MalT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-84)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10605.16 Da
• Isoelectric Point: 8.9063

>T185230 WP_001682450.1 NZ_CP066851:364503-364778 [Salmonella enterica subsp. enterica serovar Heidelberg]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIGPDWILVDKITDECLR
FERTGTHADLF

Nucleotide

• Length: 276 bp

>T185230 NZ_CP088119:581454-581939 [Enterobacter kobei]
GTGGGACGTGTAACAGCACCAGAACCATTATCCAGCTCCCATCAACTAGCAGAGTTCGTCAGTGGTGAGGCAGTACTTGA
TGACTGGCTTAAACAGAGGGGATTAAAAAACCAAGCTCTTGGTGCAGCACGAACGTTCGTCGTTTGTAAAAGAGACACTA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTGGAAGCAATGGGAAGCCTCAGACGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTTGATGTTTCATACCGTGGCCAAGGGCTCGGGGCCGATTT
ACTGCATGATGCAGTTCTGCGCTGTTACCGTGTAGCTGAGAATATTGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAACTTTTATCTTCACCATGGCTTTAAGGCATCACAAACTCAGGAACGGACATTGTTTTTAAAGTTACCA
CAGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9445.82 Da
• Isoelectric Point: 4.6028

>AT185230 WP_000729714.1 NZ_CP066851:364240-364500 [Salmonella enterica subsp. enterica serovar Heidelberg]
MAANALVRARIDETLKNQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Nucleotide

• Length: 261 bp

>AT185230 NZ_CP088119:581200-581466 [Enterobacter kobei]
ATGAAATCAGATGTTCAGCTCAACCTTAGAGCTAAAGAATCTCAAAGAGCACTTATTGATGCTGCAGCAGAGATTCTCCA
TAAATCACGCACGGACTTCATCCTGGAAATGGCATGTCAGGCTGCGGAGAATGTGATCCTCGATCGTCGCGTATTTAATT
TTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCACCGGTTTCGGATGAGGCGGCTATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U1KUN1