185161

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4045400..4046093 Replicon chromosome
Accession NZ_CP066836
Organism Escherichia coli strain Ec-FL1-1X

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JH476_RS19445 Protein ID WP_000415584.1
Coordinates 4045400..4045696 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JH476_RS19450 Protein ID WP_000650107.1
Coordinates 4045698..4046093 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH476_RS19410 (4040479) 4040479..4040793 - 315 WP_000958598.1 putative quinol monooxygenase -
JH476_RS19415 (4040824) 4040824..4041405 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JH476_RS19420 (4041733) 4041733..4042065 + 333 WP_000917684.1 DUF2645 family protein -
JH476_RS19425 (4042111) 4042111..4043460 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
JH476_RS19430 (4043457) 4043457..4044116 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
JH476_RS19435 (4044268) 4044268..4044660 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JH476_RS19440 (4044713) 4044713..4045195 + 483 WP_000183505.1 GyrI-like domain-containing protein -
JH476_RS19445 (4045400) 4045400..4045696 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JH476_RS19450 (4045698) 4045698..4046093 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JH476_RS19455 (4046226) 4046226..4047833 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
JH476_RS19460 (4047971) 4047971..4050229 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T185161 WP_000415584.1 NZ_CP066836:4045400-4045696 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T185161 NZ_CP088019:c4669380-4668493 [Pectobacterium carotovorum]
ATGCTGAAGCAACAAATTCGCCAAATCGTCCAGTCAAACCCTGACTATGCCGCAGTGACACCCGTCATAGAAAAAGAGAT
TTTGCATCATGACATTATTGATGTGTTGATCAAACAGGGCGTCATGCAGCGGTTAACGTTTATTGGCGGTACCTCATTAC
GAATGTGTTACAACAGTAGCAGGCTATCAGAAGATCTTGATTTCAATGGTGGTCATGATTTCCAGCCCTCAGCGTTTGAG
GGGCTGGAGTCCGAAATTCAAACCTATATTCAGAACAAGTATGAAACCGAAGTTTGGGTAAACAAACCTTCTGGCGCGCA
GCAAGGGGATACCGTTTCTTGGAAAATTAGTATCGTAAAAGAAGCTAATCGTCCTGATTTGCCACGGCAAAAAATGCATA
TTGACGTCTGTGCTATTCCGTCATTTGATATTGAAAAGCGCCCGCTAATCAATCATTACGACATCGTTGTACCGACTGAA
GGGATTTTGGTTCCGGTACAGTCGTTACAAGAAACATTGGCCGATAAGTTGATCGCGTTAGCGTATCGGGCAAGACGTAT
TAAACCTCGTGATATCTGGGATATCGTTTGGATTAAGCAGCGCGGTATTGATTTATCCAAGACACTGGTTGAAAAGAAGC
TCACCGCCAGACAGAAGCAAACAGAAGACTTTCGACAGGCGCTGTCTATTCAGTTAGCCAAGCTGATGTCGGAAGATGAA
GTCCGTGACGACTTCAATATGGAAATGAGCCGCTTTATTCCTAAGCAAATTAAAGAGAGAACCCTCGATAATCCTGAATA
TTGGGCTTATGTTCAGGGCGAGGTACATACCATCGCGTCTGAGTTACTGAATGACGGAACACCAAAAAATCCATTTGATA
TGGGTTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT185161 WP_000650107.1 NZ_CP066836:4045698-4046093 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT185161 NZ_CP088019:c4669933-4669409 [Pectobacterium carotovorum]
ATGGCTAAATCTGATGAGCTATTAAACGCGTTGGCCAAAGCAGTGAACGCCGGCGGCGGCATTCACAGTGTAACAGAGCT
GGCTTTTATGCAGGGTGTGCCTTGTGACTCAGCCTTTAGAAAATTCCTGGCAGATTGCGTAAAGAAGGGGTTGCTAAGAC
GAGTGGTGAAAGGCTTCTATGAAAGTGTTATTACACCACCTGAGCCTGAGACTGCCATTTATAAAATCATCAAAAAGTTG
CGCAGTGGCGTATTGAACTACATCAGCTTAGAAAGTCAGCTCAGTCATACCGGTGATATTTCACAAGTTGTGATGGGTAG
GGTCACGGTGGTGACTAAAGGTCGAAGTGGTTGTTTTGATACGCCTTATGGCGTGATCGAGCTTACCCATACTAAAAAGC
CAGTCGAGCAAATTGCACCTAATTTGTACTATGACCCTGACATCAAAATGTATCGCGCATACAAGGAACAAGCGATTGCA
GATCTAAAGCACTGCCAGCGCAATCTACATATGTTGGAGAGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References