Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 3982695..3983422 | Replicon | chromosome |
Accession | NZ_CP066836 | ||
Organism | Escherichia coli strain Ec-FL1-1X |
Toxin (Protein)
Gene name | higB | Uniprot ID | U9ZMR4 |
Locus tag | JH476_RS19145 | Protein ID | WP_000550189.1 |
Coordinates | 3982695..3983009 (+) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | D3GWQ0 |
Locus tag | JH476_RS19150 | Protein ID | WP_000560253.1 |
Coordinates | 3983006..3983422 (+) | Length | 139 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JH476_RS19125 (3978861) | 3978861..3979847 | - | 987 | WP_001377074.1 | Gfo/Idh/MocA family oxidoreductase | - |
JH476_RS19130 (3979926) | 3979926..3980609 | - | 684 | WP_001183054.1 | vancomycin high temperature exclusion protein | - |
JH476_RS19135 (3980686) | 3980686..3981189 | - | 504 | WP_001309773.1 | M48 family metallopeptidase | - |
JH476_RS19140 (3981274) | 3981274..3982410 | + | 1137 | WP_000018677.1 | 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG | - |
JH476_RS19145 (3982695) | 3982695..3983009 | + | 315 | WP_000550189.1 | type II toxin-antitoxin system toxin HigB | Toxin |
JH476_RS19150 (3983006) | 3983006..3983422 | + | 417 | WP_000560253.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
JH476_RS19155 (3983467) | 3983467..3985485 | - | 2019 | WP_000121438.1 | NADPH-dependent 2,4-dienoyl-CoA reductase | - |
JH476_RS19160 (3985656) | 3985656..3988007 | - | 2352 | WP_000695439.1 | alpha-glucosidase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 12103.10 Da Isoelectric Point: 10.0409
>T185160 WP_000550189.1 NZ_CP066836:3982695-3983009 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
Download Length: 315 bp
>T185160 NZ_CP088019:c3988944-3988528 [Pectobacterium carotovorum]
GTGAGTCGCTTGTTCATGCTGGATACCAATATCTGTTCCTTCATTATGCGTGAACACCCTGCGGAGGTGATTGAAAAGTT
GCAGCAGTGCACGTTGCGGCGTGATCGGATTGTGGTCTCTGCCATCACTTACGCTGAAATGCGTTTCGGGGCGGTTGGCA
AAAAAGCCTCGCCACGCCATATGCAACTAGTTGATGCTTTCTGTCGCCGGCTTGATGCGGTGTTACCTTGGGATAGCGCC
GCAGTAGACGCTACGACGAAAATTAAAATCGCGCTAGCCGCAGCAGGCACGCCTATAGGCCCGAATGATACGGCCATCGC
GGGTCATGCCATCAGTGCTAAGGCCATATTGGTCACCAATAATCTGAGAGAATTTGAGCGAGTACCGGGGCTGACGTTGG
AAGATTGGGTTAAATAA
GTGAGTCGCTTGTTCATGCTGGATACCAATATCTGTTCCTTCATTATGCGTGAACACCCTGCGGAGGTGATTGAAAAGTT
GCAGCAGTGCACGTTGCGGCGTGATCGGATTGTGGTCTCTGCCATCACTTACGCTGAAATGCGTTTCGGGGCGGTTGGCA
AAAAAGCCTCGCCACGCCATATGCAACTAGTTGATGCTTTCTGTCGCCGGCTTGATGCGGTGTTACCTTGGGATAGCGCC
GCAGTAGACGCTACGACGAAAATTAAAATCGCGCTAGCCGCAGCAGGCACGCCTATAGGCCCGAATGATACGGCCATCGC
GGGTCATGCCATCAGTGCTAAGGCCATATTGGTCACCAATAATCTGAGAGAATTTGAGCGAGTACCGGGGCTGACGTTGG
AAGATTGGGTTAAATAA
Antitoxin
Download Length: 139 a.a. Molecular weight: 14965.39 Da Isoelectric Point: 4.4547
>AT185160 WP_000560253.1 NZ_CP066836:3983006-3983422 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYAQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
MIAIADILQAGEKLTAVAPFLAGIQNEEQYAQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
Download Length: 417 bp
>AT185160 NZ_CP088019:c3989168-3988941 [Pectobacterium carotovorum]
ATGCGTATTGTTTCGGTATTTAAAAACGGTAACAACCGTGCCATTCGCTTGCCACGTGATATGGACTTTGAAGGGGTCAA
CGAACTGGAGATTGTGCGTGAGGGAGATACCATCATGCTTCGTCCGGTCAAACCCAATTGGCATTCGTTTTTGCAAGAAG
ATCGCGCTGACGCTGACTTTATGACAGAACGTCAGGATGTGGTCGAGGAGGGGAGATTCGAACTGTGA
ATGCGTATTGTTTCGGTATTTAAAAACGGTAACAACCGTGCCATTCGCTTGCCACGTGATATGGACTTTGAAGGGGTCAA
CGAACTGGAGATTGTGCGTGAGGGAGATACCATCATGCTTCGTCCGGTCAAACCCAATTGGCATTCGTTTTTGCAAGAAG
ATCGCGCTGACGCTGACTTTATGACAGAACGTCAGGATGTGGTCGAGGAGGGGAGATTCGAACTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 6KMQ | |
PDB | 5IFG | |
PDB | 5YCL | |
PDB | 6KML |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829IXD3 |