185153

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2371742..2372000 Replicon chromosome
Accession NZ_CP066836
Organism Escherichia coli strain Ec-FL1-1X

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag JH476_RS11460 Protein ID WP_000809168.1
Coordinates 2371848..2372000 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 2371742..2371799 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH476_RS11445 2368134..2369093 + 960 WP_000871674.1 hypothetical protein -
JH476_RS11450 2369131..2370030 - 900 WP_001300855.1 transcriptional activator NhaR -
JH476_RS11455 2370096..2371262 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 2371742..2371799 - 58 - - Antitoxin
JH476_RS11460 2371848..2372000 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
JH476_RS11465 2372104..2373234 - 1131 WP_001118464.1 molecular chaperone DnaJ -
JH476_RS11470 2373323..2375239 - 1917 WP_000516135.1 molecular chaperone DnaK -
JH476_RS11475 2375615..2376019 + 405 WP_000843584.1 DUF2541 family protein -
JH476_RS11480 2376045..2376758 + 714 WP_001102367.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T185153 WP_000809168.1 NZ_CP066836:2371848-2372000 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T185153 NZ_CP088019:c507690-507439 [Pectobacterium carotovorum]
ATGCGTACAATTAGCTACAGTGAAGCCCGACAAAATCTATCGGCGACCATGATGAAAACGGTCGAAGACCGTGCTCCCAT
TCTTATCACCCGACAGAATGGTGAAGCCTGCGTGCTCATGTCTTTGGAAGAGTATAACTCTCTAGAGGAGACCGCGTATT
TACTGCGTTCACCAGCCAATGCAAAAAGACTGATGAACTCAATCGAGAGCCTTAAGGCTGGCAATGGCAAAGAAAGAGAT
ATCATTGAGTGA

Antitoxin


Download         Length: 58 bp

>AT185153 NZ_CP066836:c2371799-2371742 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References