Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 105543..106045 | Replicon | chromosome |
| Accession | NZ_CP066836 | ||
| Organism | Escherichia coli strain Ec-FL1-1X | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | JH476_RS00510 | Protein ID | WP_000767829.1 |
| Coordinates | 105791..106045 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | JH476_RS00505 | Protein ID | WP_001259255.1 |
| Coordinates | 105543..105794 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JH476_RS00480 (100721) | 100721..101788 | - | 1068 | WP_000080093.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| JH476_RS00485 (101788) | 101788..102858 | - | 1071 | WP_001468894.1 | histidinol-phosphate transaminase | - |
| JH476_RS00490 (102855) | 102855..104159 | - | 1305 | WP_021547561.1 | histidinol dehydrogenase | - |
| JH476_RS00495 (104165) | 104165..105064 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| JH476_RS00500 (105210) | 105210..105260 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| JH476_RS00505 (105543) | 105543..105794 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| JH476_RS00510 (105791) | 105791..106045 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| JH476_RS00515 (106128) | 106128..106952 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| JH476_RS00520 (106998) | 106998..107927 | + | 930 | WP_000803360.1 | LysR substrate-binding domain-containing protein | - |
| JH476_RS00525 (108142) | 108142..108204 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| JH476_RS00530 (108194) | 108194..109552 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| JH476_RS00535 (109731) | 109731..110789 | + | 1059 | WP_000492340.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| JH476_RS00540 (110803) | 110803..111030 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T185137 WP_000767829.1 NZ_CP066836:105791-106045 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T185137 NZ_CP088009:1120020-1120544 [Rhizobium sp. T136]
GTGGCTTTATCGGTTCCCGAACCTCTTACCGCTGGACATGATGTTTCCGAGTTCTCCTGCGGCAAGCCTACGCTCGATCA
TTGGCTGAAGACGCGCGCTCTTTCCAATCAGGAAAAGGGTTTCACGGCGATTCTCGTTGTCCGCGAGGCCGGGCGAGTCG
TCGGGTATTACGGCCTGGCGCCGACGGCCGTCATTCCTTCGATCCTGCCGCGCTCGATCCGCACAGAGCAACCGCCCGAT
CCGGTTCCCTGTCTTCTTCTCGGCCAGCTTGCCACGGATACGGAATGGGCCGGGCGCGGCATCGGCACAGGTCTGGTGAA
ACATGCCCTTGAGCGCTGCGTTCAGGCCGCAGTTCTCATTGGCGGACGGGCATTAATGGTCAACGCCGTCGATCACGAAG
CGGCTCAGTTCTGGCAGCGCCGAGGTTTCACGCCCTCGAAGGACGACCCGCTCGTGCTGTTTCGCTCGATCGCTGCAATC
GCCGCATCGCTGGCGGAAGCGCGGCAGCAAGAGCGAGGCACATAA
GTGGCTTTATCGGTTCCCGAACCTCTTACCGCTGGACATGATGTTTCCGAGTTCTCCTGCGGCAAGCCTACGCTCGATCA
TTGGCTGAAGACGCGCGCTCTTTCCAATCAGGAAAAGGGTTTCACGGCGATTCTCGTTGTCCGCGAGGCCGGGCGAGTCG
TCGGGTATTACGGCCTGGCGCCGACGGCCGTCATTCCTTCGATCCTGCCGCGCTCGATCCGCACAGAGCAACCGCCCGAT
CCGGTTCCCTGTCTTCTTCTCGGCCAGCTTGCCACGGATACGGAATGGGCCGGGCGCGGCATCGGCACAGGTCTGGTGAA
ACATGCCCTTGAGCGCTGCGTTCAGGCCGCAGTTCTCATTGGCGGACGGGCATTAATGGTCAACGCCGTCGATCACGAAG
CGGCTCAGTTCTGGCAGCGCCGAGGTTTCACGCCCTCGAAGGACGACCCGCTCGTGCTGTTTCGCTCGATCGCTGCAATC
GCCGCATCGCTGGCGGAAGCGCGGCAGCAAGAGCGAGGCACATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT185137 WP_001259255.1 NZ_CP066836:105543-105794 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT185137 NZ_CP088009:1119717-1120016 [Rhizobium sp. T136]
ATGGCCACCACCGTCGAACGCAAGGAATACCCGATCTCGATGCGTCTGCCCGAAGCGGACGTCGCGATGATCGATCGAGC
CGCCACGCTGCGCGGCCGGTCGCGCACCGATTTCGTGCGCGATGCAGCCGTGCGCGCGGCCGAAGAAATCGTCATGGAAC
AGCGACTGATCCGCATGAGCCCCGAAGGCTTCGCCGATTTCATGGACGTCCTGTCCCGCCCGGCTGCTCCGGTTCCCGAG
ATGGTGAAACTGGCCAAGCGGCCCGCGGCGTGGGAACCAGGCTACGTCGCGAAGCGGTGA
ATGGCCACCACCGTCGAACGCAAGGAATACCCGATCTCGATGCGTCTGCCCGAAGCGGACGTCGCGATGATCGATCGAGC
CGCCACGCTGCGCGGCCGGTCGCGCACCGATTTCGTGCGCGATGCAGCCGTGCGCGCGGCCGAAGAAATCGTCATGGAAC
AGCGACTGATCCGCATGAGCCCCGAAGGCTTCGCCGATTTCATGGACGTCCTGTCCCGCCCGGCTGCTCCGGTTCCCGAG
ATGGTGAAACTGGCCAAGCGGCCCGCGGCGTGGGAACCAGGCTACGTCGCGAAGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|