Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 70575..71094 Replicon chromosome
Accession NZ_CP066802
Organism Actinomyces weissii strain CCUG 61299

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag JG540_RS00310 Protein ID WP_200275943.1
Coordinates 70575..70835 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag JG540_RS00315 Protein ID WP_200275945.1
Coordinates 70837..71094 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG540_RS00295 65765..66583 - 819 WP_200275936.1 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase -
JG540_RS00300 66862..68916 + 2055 WP_200275939.1 alpha-amylase -
JG540_RS00305 68963..70492 + 1530 WP_200275941.1 L-serine ammonia-lyase -
JG540_RS00310 70575..70835 - 261 WP_200275943.1 Txe/YoeB family addiction module toxin Toxin
JG540_RS00315 70837..71094 - 258 WP_200275945.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JG540_RS00320 71507..73144 + 1638 WP_200275947.1 DUF262 domain-containing protein -
JG540_RS00325 73141..74367 + 1227 WP_200275949.1 HipA domain-containing protein -
JG540_RS00330 74760..75248 + 489 WP_200275951.1 Asp23/Gls24 family envelope stress response protein -
JG540_RS00335 75280..75456 + 177 WP_200275953.1 hypothetical protein -
JG540_RS00340 75459..75881 + 423 WP_200275955.1 Asp23/Gls24 family envelope stress response protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10215.60 Da        Isoelectric Point: 8.9018

>T185047 WP_200275943.1 NZ_CP066802:c70835-70575 [Actinomyces weissii]
VALIWDESAWADYLWWQAQDRKILKRINQLLRDVQRGGHEGLGKPEPLRHSLTGYWSRRITAEHRLVYRIDDAGNILVAA
CRYHYE

Download         Length: 261 bp

>T185047 NZ_CP087880:4899920-4900072 [Pseudocitrobacter corydidari]
ATGCTAACAAAATATGCCCTTGTGGCAATCATAGTGCTGTGTTTTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GCTGTGTGAGTTGAGTATCAGAGAGCGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9435.62 Da        Isoelectric Point: 4.4915

>AT185047 WP_200275945.1 NZ_CP066802:c71094-70837 [Actinomyces weissii]
MKTMTYTESRARYAEVLDSVVNDCEEVVITRAGHEPAVIVSLAEYQSLKETDYLLRNPANAKRLLAAVERLDGGVGAQHE
LIETD

Download         Length: 258 bp

>AT185047 NZ_CP087880:c4899875-4899827 [Pseudocitrobacter corydidari]
GTTCGAACGCGAGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References