Detailed information of TA system TA185044

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3194970..3195228
• Replicon: chromosome
• Accession: NZ_CP066796
• Organism: Erwinia amylovora strain ATCC 15580

Toxin (Protein)

• Gene name: hok
• Uniprot ID: D4I1C1
• Locus tag: JGC47_RS14605
• Protein ID: WP_004160031.1
• Coordinates: 3194970..3195128 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	3195182..3195228 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JGC47_RS14590	3190275..3191966	-	1692	WP_004160025.1	chloride channel protein	-
JGC47_RS14595	3192379..3193359	+	981	WP_013035818.1	TerC family protein	-
JGC47_RS14600	3193594..3194826	+	1233	WP_004160030.1	serine/threonine transporter SstT	-
JGC47_RS14605	3194970..3195128	-	159	WP_004160031.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	3195182..3195228	+	47	-	-	Antitoxin
JGC47_RS14610	3195939..3196613	+	675	WP_004160034.1	DedA family protein	-
JGC47_RS14615	3196610..3197002	+	393	WP_004160035.1	EnvZ/OmpR regulon moderator MzrA	-
JGC47_RS14620	3197170..3197541	+	372	WP_004160036.1	DUF1090 domain-containing protein	-
JGC47_RS14625	3197584..3197889	+	306	WP_004160037.1	DUF883 family protein	-
JGC47_RS14630	3197891..3198283	+	393	WP_004160038.1	phage holin family protein	-
JGC47_RS14635	3198283..3198564	+	282	WP_004160039.1	YqjK-like family protein	-
JGC47_RS14640	3198774..3199166	+	393	WP_004160048.1	DoxX family protein	-
JGC47_RS14645	3199639..3199782	+	144	WP_004160049.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (8-48)

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 6038.32 Da
• Isoelectric Point: 8.4901

>T185044 WP_004160031.1 NZ_CP066796:c3195128-3194970 [Erwinia amylovora]
MKLPANCLIWCVLIVCVTLLIFTYLTRKSLCEIRYKDGYREVAAFMAYESGK

Nucleotide

• Length: 159 bp

>T185044 NZ_CP087880:c4480997-4480524 [Pseudocitrobacter corydidari]
ATGGACTTTCCGCATAAAGTGAATGGTTGGGCGCTCTACGCTCATCCCTGCTTTCAGGAAACTTATGATGCTTTAGTTGA
AGATGTCGAGATATTAAAGGGAAAGGATCCTGAGAATTATCAAAAGAAAGCAGCCACCAGGCTGTTGGCCGTTGTACACA
AAGTTATTGAGGAACACATCACCGTCTCTCCTTCATCACCATCATTTCGTCATGGGAAGACGTTAGGAACAGGTAATCAT
AAAGATTGGTCGAGAGCTAAATTCGGCGCGGGAAGGTATCGACTCTTTTTCCGGTACAGTGAAAAAGAGAGAGTTATCAT
CCTGGGGTGGATGAACGATGAACACACGCTCAGAAGCTACGGCAAAAAGAGTGACGCTTATACCACCTTCTGCAAAATGT
TGAAGAAGGGGCACCCACCCGCCGATTGGGAAAGTCTTCTGCAAGAAGCCCTGACAAGCGCGAAACGTAAATAA

Antitoxin

Nucleotide

• Length: 47 bp

>AT185044 NZ_CP066796:3195182-3195228 [Erwinia amylovora]
GCATGCAGATGGCCTCGTGGATTAATGAAAATTAACTACGGGGCTTT

Structures

Toxin

• AlphaFold DB: A0A831A7I1

Antitoxin