Detailed information of TA system TA185034

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3191851..3192109
• Replicon: chromosome
• Accession: NZ_CP066794
• Organism: Erwinia amylovora strain 17-2187

Toxin (Protein)

• Gene name: hok
• Uniprot ID: D4I1C1
• Locus tag: JGC41_RS14585
• Protein ID: WP_004160031.1
• Coordinates: 3191851..3192009 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	3192063..3192109 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JGC41_RS14570	3187156..3188847	-	1692	WP_004160025.1	chloride channel protein	-
JGC41_RS14575	3189260..3190240	+	981	WP_013035818.1	TerC family protein	-
JGC41_RS14580	3190475..3191707	+	1233	WP_004160030.1	serine/threonine transporter SstT	-
JGC41_RS14585	3191851..3192009	-	159	WP_004160031.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	3192063..3192109	+	47	-	-	Antitoxin
JGC41_RS14590	3192820..3193494	+	675	WP_004160034.1	DedA family protein	-
JGC41_RS14595	3193491..3193883	+	393	WP_004160035.1	EnvZ/OmpR regulon moderator MzrA	-
JGC41_RS14600	3194051..3194422	+	372	WP_004160036.1	DUF1090 domain-containing protein	-
JGC41_RS14605	3194465..3194770	+	306	WP_004160037.1	DUF883 family protein	-
JGC41_RS14610	3194772..3195164	+	393	WP_004160038.1	phage holin family protein	-
JGC41_RS14615	3195164..3195445	+	282	WP_004160039.1	YqjK-like family protein	-
JGC41_RS14620	3195655..3196047	+	393	WP_004160048.1	DoxX family protein	-
JGC41_RS14625	3196520..3196663	+	144	WP_004160049.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (8-48)

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 6038.32 Da
• Isoelectric Point: 8.4901

>T185034 WP_004160031.1 NZ_CP066794:c3192009-3191851 [Erwinia amylovora]
MKLPANCLIWCVLIVCVTLLIFTYLTRKSLCEIRYKDGYREVAAFMAYESGK

Nucleotide

• Length: 159 bp

>T185034 NZ_CP087880:c3301242-3300892 [Pseudocitrobacter corydidari]
ATGGTAAAAAGCCCAATGTTTGCGCGCGGCGATATTGTGCTGGTGGGGTTTGACCCCGCGAGCGGGCACGAACAAAAGGG
CGAAGGGCGTCCTGCATTAGTGCTCTCTGTTAGCGCCTTTAATCGCTTAGGAATGGTGCTTGTCGCGCCTGTTACACGCG
GTGGAAACCATGCGCGTTATGCCGGTTTCGCTGTTCCACTGAGCTGCAAAACCGGCGACGTCAGCGGCGTTGTGCTGGTT
AATCAGTTTCGCATGATGGATCTTAACGCGCGTGGGGCAAAGAAACTGGGCGAAGCAAGCGCGGAAGTGGTGGAAGATGT
GTTACTTCGGGCACAGGCAATTCTTGATTAG

Antitoxin

Nucleotide

• Length: 47 bp

>AT185034 NZ_CP066794:3192063-3192109 [Erwinia amylovora]
GCATGCAGATGGCCTCGTGGATTAATGAAAATTAACTACGGGGCTTT

Structures

Toxin

• AlphaFold DB: A0A831A7I1

Antitoxin