Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2152732..2153380 Replicon chromosome
Accession NZ_CP066777
Organism Morganella morganii strain FAM24091

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CXB74_RS10190 Protein ID WP_107679151.1
Coordinates 2152732..2153076 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CXB74_RS10195 Protein ID WP_107679152.1
Coordinates 2153081..2153380 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXB74_RS10180 (CXB74_010025) 2148332..2149429 + 1098 WP_107679149.1 efflux RND transporter periplasmic adaptor subunit -
CXB74_RS10185 (CXB74_010030) 2149426..2152515 + 3090 WP_107679150.1 efflux RND transporter permease subunit -
CXB74_RS10190 (CXB74_010035) 2152732..2153076 + 345 WP_107679151.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CXB74_RS10195 (CXB74_010040) 2153081..2153380 + 300 WP_107679152.1 helix-turn-helix transcriptional regulator Antitoxin
CXB74_RS10200 (CXB74_010045) 2153434..2154306 - 873 WP_107679153.1 dimethyl sulfoxide reductase anchor subunit -
CXB74_RS10205 (CXB74_010050) 2154303..2154932 - 630 WP_107679154.1 dimethylsulfoxide reductase subunit B -
CXB74_RS10210 (CXB74_010055) 2154929..2157313 - 2385 WP_107679155.1 molybdopterin-dependent oxidoreductase -
CXB74_RS10215 (CXB74_010060) 2157679..2158167 - 489 WP_107679156.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13331.30 Da        Isoelectric Point: 8.8135

>T185018 WP_107679151.1 NZ_CP066777:2152732-2153076 [Morganella morganii]
VWTVLLTDYFNEWLSKQDTRMKEKVLASLGNLEIYGPVLTRPYVDTVKTSQYPNMKELRIWHAGRAIRAFFAFDPERQAI
ILCAGDKGKDKRFYQTMIRIADEQFSSYLSATQE

Download         Length: 345 bp

>T185018 NZ_CP087865:1167554-1167811 [Moraxella bovis]
TTGAGGATTAGATGGTTTGATGAGGTATGGGAGGATTATTTGTATTGGCAAAGCCAAGATAAGAAAACCATAAAACGTAT
TAATACCTTGATTAAGGATTGCAGACGAGACCCTTTTGACGGTATCGGCAAACCCGAACCATTAAAATATAACCTAACAG
GCTACTGGTTAAGACGCATTAATGATGCCAACCGCTTGGTTTATTGTTGCGAAAGTGAAACACTCATCATTTCATGCCGT
CATCATTATGAGGCTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11166.90 Da        Isoelectric Point: 7.0156

>AT185018 WP_107679152.1 NZ_CP066777:2153081-2153380 [Morganella morganii]
MKTLQEVIAAQSPESRERIKQLTDELVLETGLQLLREELHISQKTLANNLGISQPAVTQIEQRGNDIKLATLKRYIEAMG
GTLRLTIELPTGDNRIFRV

Download         Length: 300 bp

>AT185018 NZ_CP087865:1167322-1167564 [Moraxella bovis]
ATGAATTATAGCGAATTTCGCCAAAACCTAGCCTCTGCCCTTGATTATGTTCAAGACAGCCATGCCCCTGTGATTGTCAA
ACGTGGCAAACATTCTGCGGTGGTGATTAGTCTTGATGAATATAATGCTTTTAAAGAAACAGATTATCTATTGTCAAACC
CTGCTAATGCCGAACACCTTATGCGTGGCGTGCAAGCGGTAAAAAATCGTCAACTTACCCAAAGGGATTTGATTGAGGAT
TAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References