Detailed information of TA system TA185017

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1692967..1693625
• Replicon: chromosome
• Accession: NZ_CP066777
• Organism: Morganella morganii strain FAM24091

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: CXB74_RS07775
• Protein ID: WP_107678433.1
• Coordinates: 1692967..1693320 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CXB74_RS07780
• Protein ID: WP_046892450.1
• Coordinates: 1693323..1693625 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXB74_RS07765 (CXB74_007645)	1691146..1691403	-	258	WP_107678432.1	biofilm formation regulator BssS	-
CXB74_RS07770 (CXB74_007650)	1691638..1692690	-	1053	WP_107678459.1	dihydroorotase	-
CXB74_RS07775 (CXB74_007655)	1692967..1693320	+	354	WP_107678433.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CXB74_RS07780 (CXB74_007660)	1693323..1693625	+	303	WP_046892450.1	XRE family transcriptional regulator	Antitoxin
CXB74_RS07805 (CXB74_007685)	1694752..1695261	-	510	WP_107678434.1	YlaC family protein	-
CXB74_RS07810 (CXB74_007690)	1695719..1695931	+	213	WP_004240014.1	transcription antiterminator/RNA stability regulator CspE	-
CXB74_RS07815 (CXB74_007695)	1696035..1696229	+	195	WP_046892448.1	protein DsrB	-
CXB74_RS07820 (CXB74_007700)	1696581..1697276	+	696	WP_046892447.1	MgtC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-81)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13412.31 Da
• Isoelectric Point: 9.7296

>T185017 WP_107678433.1 NZ_CP066777:1692967-1693320 [Morganella morganii]
VWKIITTDNFAAWFAAQDDGDRTAILAAMLVLEKTGPGLSGPYADTVKGSRYTNMKELRIQSRGQPIRAFFAFDPERRGV
LLCAGYKTGKEKRFYMQMIPQADREYTEWLNRPENRS

Nucleotide

• Length: 354 bp

>T185017 NZ_CP087865:1167322-1167564 [Moraxella bovis]
ATGAATTATAGCGAATTTCGCCAAAACCTAGCCTCTGCCCTTGATTATGTTCAAGACAGCCATGCCCCTGTGATTGTCAA
ACGTGGCAAACATTCTGCGGTGGTGATTAGTCTTGATGAATATAATGCTTTTAAAGAAACAGATTATCTATTGTCAAACC
CTGCTAATGCCGAACACCTTATGCGTGGCGTGCAAGCGGTAAAAAATCGTCAACTTACCCAAAGGGATTTGATTGAGGAT
TAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11093.93 Da
• Isoelectric Point: 8.5490

>AT185017 WP_046892450.1 NZ_CP066777:1693323-1693625 [Morganella morganii]
MGKSLRQLLAEEKPEVAAAARVQADEILLNIHLAELREKVNKTQVEMAQALGIKQPTVAGMEKPGRDVKLSTLRRYVDAI
GGKLNIDVELPDGTHYMFRV

Nucleotide

• Length: 303 bp

>AT185017 NZ_CP087865:1167554-1167811 [Moraxella bovis]
TTGAGGATTAGATGGTTTGATGAGGTATGGGAGGATTATTTGTATTGGCAAAGCCAAGATAAGAAAACCATAAAACGTAT
TAATACCTTGATTAAGGATTGCAGACGAGACCCTTTTGACGGTATCGGCAAACCCGAACCATTAAAATATAACCTAACAG
GCTACTGGTTAAGACGCATTAATGATGCCAACCGCTTGGTTTATTGTTGCGAAAGTGAAACACTCATCATTTCATGCCGT
CATCATTATGAGGCTTAA