Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 7299342..7299919 Replicon chromosome
Accession NZ_CP066774
Organism Streptomyces murinus strain Am1

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag JGK51_RS32140 Protein ID WP_128789975.1
Coordinates 7299662..7299919 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JGK51_RS32135 Protein ID WP_162133890.1
Coordinates 7299342..7299665 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGK51_RS32115 7294558..7295742 + 1185 WP_199573616.1 GNAT family N-acetyltransferase -
JGK51_RS32120 7296053..7297114 + 1062 WP_162133893.1 glycoside hydrolase family 11 protein -
JGK51_RS32125 7297289..7297984 + 696 WP_199573618.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
JGK51_RS32130 7298107..7299255 + 1149 WP_199573620.1 FAD-dependent monooxygenase -
JGK51_RS32135 7299342..7299665 - 324 WP_162133890.1 helix-turn-helix transcriptional regulator Antitoxin
JGK51_RS32140 7299662..7299919 - 258 WP_128789975.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JGK51_RS32145 7300095..7301798 + 1704 WP_162133888.1 ABC transporter substrate-binding protein -
JGK51_RS32150 7301803..7302765 + 963 WP_162133887.1 ABC transporter permease -
JGK51_RS32155 7302762..7304717 + 1956 WP_199573622.1 dipeptide/oligopeptide/nickel ABC transporter permease/ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-72)

Antitoxin

Cro/C1-type helix-turn-helix domain

(41-89)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9890.04 Da        Isoelectric Point: 4.4179

>T185013 WP_128789975.1 NZ_CP066774:c7299919-7299662 [Streptomyces murinus]
VEEQWDVYLTAEVDQWLHDLKELRPGSTGRSEVRVLFMFDPWRSAILLTAGDKAGDWGAWYERAIPLAERAYTEYLADRE
KESGK

Download         Length: 258 bp

>T185013 NZ_CP087863:c2350995-2350693 [Moraxella bovis]
ATGACCAAGTCTGATAAATTAAAAGCCAAATTGTATGGCGATGTACGAACTTTTGTATTTAGTGATTTGGTTACTTTATT
ATCGCAATTAGGTTATGAAATGCACGAACGGGCAGGTTCTCGTGTGGTATTTGTTCATTGTGATGATAATAGCGACCGCA
TTCATTTGCATAAACCCCACCCCGAAAATACCATTAAAGGTGGAGCATTAAAAGCGGTCAAAGCCTATTTGTCCGAAAAA
GGCTATTTTGATGAATTTAATGATGATGTGTTAAATCAGGAGCTTAAAAATGATGACCTATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11658.20 Da        Isoelectric Point: 9.8243

>AT185013 WP_162133890.1 NZ_CP066774:c7299665-7299342 [Streptomyces murinus]
MSGYTKWSGSGHRERAEELAGGREPFFAGAERLLAQARAWRLVEMRQERGFTQAQVAERMGVSKGRVSQIESGQVSGTEV
VARYVEALGGNLVMVAVFADGELRKVG

Download         Length: 324 bp

>AT185013 NZ_CP087863:c2350706-2350371 [Moraxella bovis]
ATGATGACCTATAAAGGCTATGTTGGCGAATTTACGCTTGATAATGATGATGAAATATTTTATGGTAAACTTATTGGCAT
TAATCAGCTTGTTACTTTTGAAGCAGACAATGCCCATGATTTAAAACAAGCCTTTTATGACAGCGTGGACGATTATTTGG
CGTTTTGTGCTGAACAAGGCATAGAGCCTGATAAGCCTTTTAAGGGTTCATTTAATGTGCGTATTGATAGCGAATTGCAC
CGCCGTGCTTATATGGCAAGCCGTGACAGTAGTTTAAATGCGTTTGTAGGACAAGCCATTAGTGAAAAGCTAAATAGAAT
GGCTGTATCAATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References