Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1287244..1287947 Replicon chromosome
Accession NZ_CP066772
Organism Ralstonia pickettii strain K-288

Toxin (Protein)


Gene name mqsR Uniprot ID U3GCL7
Locus tag RP6297_RS21880 Protein ID WP_009241850.1
Coordinates 1287648..1287947 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID U3GCL8
Locus tag RP6297_RS21875 Protein ID WP_009241849.1
Coordinates 1287244..1287645 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RP6297_RS21855 1282325..1283533 + 1209 WP_037028908.1 acyl-CoA/acyl-ACP dehydrogenase -
RP6297_RS21860 1283663..1284253 + 591 WP_198286347.1 cysteine dioxygenase -
RP6297_RS21865 1284250..1285899 + 1650 WP_009241847.1 rhodanese-related sulfurtransferase -
RP6297_RS21870 1286294..1287181 + 888 WP_009241848.1 EamA family transporter -
RP6297_RS21875 1287244..1287645 - 402 WP_009241849.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
RP6297_RS21880 1287648..1287947 - 300 WP_009241850.1 type II toxin-antitoxin system MqsR family toxin Toxin
RP6297_RS21885 1288020..1290032 - 2013 WP_009241851.1 EAL domain-containing protein -
RP6297_RS21890 1290029..1290601 - 573 WP_009241852.1 YfiR family protein -
RP6297_RS21895 1290598..1292613 - 2016 WP_009241853.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-98)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11117.92 Da        Isoelectric Point: 9.5040

>T185011 WP_009241850.1 NZ_CP066772:c1287947-1287648 [Ralstonia pickettii]
MEKRTPHAKLSLIRELIRSGSVRATRSAYEGALELGITDLAGMCAVVMTLTPHSFYKSMTTHADHRVWQDVYHTKARGQD
VYLKLTVVDGVLIVSFKEL

Download         Length: 300 bp

>T185011 NZ_CP087863:c1798855-1798520 [Moraxella bovis]
ATGTGCGAATTAATGTATGAATTAGAATTTGACGAGCGAGCCTTAAAAGAATGGCAAAAACTGGGCGACACCATAAAAAC
GCAGTTTAAAAAGAGACTGGCTAAGGTGCTAAAAAATCCGCACATCATCGCCAATCGCCTAAGCGGTGGACAAAATTTAT
ACAAAATCAACTTCCGCTCGGCAGGTTATCGCCTTGTGTATCAAGTTGAAGATGATAAAGTGGTGGTGTTTGTCATCGTG
ATGGGTAAGCGTGAGAAAAATGCCGTCTATGACACCGCCGAAGAATGGCTTGCTGAACGTCAATCGGACAATCAAGACAC
ACAATCTGTCAAATAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14642.68 Da        Isoelectric Point: 5.6828

>AT185011 WP_009241849.1 NZ_CP066772:c1287645-1287244 [Ralstonia pickettii]
MKCPSCGAAELVHDTRDVPYAYKGETTVIPSVTGEFCPACDEIVLEREQGDRYGELVSAFQRQVNATYVDPAYIAAVRRK
LNLDQREAAEIFGGGVNAFSRYETGKTKPSLALVKLLKLLDHHPDLLAEIKTA

Download         Length: 402 bp

>AT185011 NZ_CP087863:c1799097-1798855 [Moraxella bovis]
ATGGCAAATATCGTGGCTCGTGTGGACGATGACCTAAAAGCCCAATCATTTTTGGTACTGCAAGAACTTGGCGTGACACC
GTCCGAGCTTATCCGCCAAACCTTGCAATATGTGGCTTATCACAAAAAATTACCCTTTAAGACGGTGGTTTTGACCGATG
AAGACAGTGAGCTTTTAGCCCTTGCCAAAGAACGCCTTGATAATCCTGCCCCACGCATCAAAGTCAGTTTGGACGAGCTT
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P4RCS3

Antitoxin

Source ID Structure
AlphaFold DB A0A7X2L9J0

References