Detailed information of TA system TA184956

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 4725886..4726298
• Replicon: chromosome
• Accession: NZ_CP066756
• Organism: Escherichia coli O157:H7 strain ECP19-798

Toxin (Protein)

• Gene name: symE
• Uniprot ID: Q8FA88
• Locus tag: JG530_RS23590
• Protein ID: WP_000132630.1
• Coordinates: 4725957..4726298 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4725886..4725962 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JG530_RS23580	4722513..4723982	+	1470	WP_001302468.1	type I restriction-modification system subunit M	-
JG530_RS23585	4723982..4725736	+	1755	WP_000110082.1	restriction endonuclease subunit S	-
-	4725886..4725962	-	77	NuclAT_15	-	Antitoxin
-	4725886..4725962	-	77	NuclAT_15	-	Antitoxin
-	4725886..4725962	-	77	NuclAT_15	-	Antitoxin
-	4725886..4725962	-	77	NuclAT_15	-	Antitoxin
-	4725886..4725962	-	77	NuclAT_16	-	Antitoxin
-	4725886..4725962	-	77	NuclAT_16	-	Antitoxin
-	4725886..4725962	-	77	NuclAT_16	-	Antitoxin
-	4725886..4725962	-	77	NuclAT_16	-	Antitoxin
JG530_RS23590	4725957..4726298	+	342	WP_000132630.1	endoribonuclease SymE	Toxin
JG530_RS23595	4726345..4727508	-	1164	WP_001304006.1	DUF1524 domain-containing protein	-
JG530_RS23600	4727556..4728437	-	882	WP_001304007.1	DUF262 domain-containing protein	-
JG530_RS23605	4728534..4728698	-	165	WP_000394274.1	DUF1127 domain-containing protein	-
JG530_RS23610	4728875..4730287	+	1413	WP_000199295.1	PLP-dependent aminotransferase family protein	-
JG530_RS23615	4730530..4730730	-	201	WP_001310455.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12294.13 Da
• Isoelectric Point: 8.4982

>T184956 WP_000132630.1 NZ_CP066756:4725957-4726298 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T184956 NZ_CP087851:2058733-2058993 [Moraxella bovis]
ATTGAGGCCTTATTTGTAGCATTAGGGGCGGACATCTCTGAGCGAGCAGGTTCACGCATGGCTGTGGCGCTAAACGGGCA
AGTCATGGTTTTTCATCGCCCACACCCAAGCCCAAATACTGACAAAAGTGCGGTTATGAGCATTAGAAAATGGCTTGATG
GCATGGGTATCACACCATTAGATGACGACAGCCAAACAGACGAATACGCAGACAAACAAACCGACGAACAGGAGCAGACT
CATGAACACAATGACAATTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT184956 NZ_CP066756:c4725962-4725886 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0E0Y5T0

Antitoxin