184913

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3341404..3342199 Replicon chromosome
Accession NZ_CP066753
Organism Escherichia coli O157:H7 strain ECP19-598

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag JG531_RS17165 Protein ID WP_000854914.1
Coordinates 3341404..3341778 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag JG531_RS17170 Protein ID WP_001280954.1
Coordinates 3341825..3342199 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG531_RS17125 3336408..3336899 - 492 WP_001301587.1 DUF1097 domain-containing protein -
JG531_RS17130 3337001..3337555 - 555 WP_001001917.1 molecular chaperone YcdY -
JG531_RS17135 3337579..3338316 - 738 WP_000283664.1 zinc-binding phosphatase -
JG531_RS17140 3338371..3339309 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
JG531_RS17150 3339780..3340622 - 843 WP_001280481.1 DUF4942 domain-containing protein -
JG531_RS17155 3340707..3340904 - 198 WP_000839282.1 DUF957 domain-containing protein -
JG531_RS17160 3340916..3341407 - 492 WP_000976853.1 hypothetical protein -
JG531_RS17165 3341404..3341778 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
JG531_RS17170 3341825..3342199 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JG531_RS17175 3342362..3342583 - 222 WP_001220314.1 DUF987 domain-containing protein -
JG531_RS17180 3342646..3343122 - 477 WP_001186738.1 RadC family protein -
JG531_RS17185 3343138..3343623 - 486 WP_000214398.1 antirestriction protein -
JG531_RS17190 3343714..3344532 - 819 WP_001234682.1 DUF945 domain-containing protein -
JG531_RS17195 3344872..3345942 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
JG531_RS17200 3345939..3346844 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 3332790..3343623 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T184913 WP_000854914.1 NZ_CP066753:c3341778-3341404 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T184913 NZ_CP087840:c2251070-2250882 [Moraxella bovis]
ATGCCCCCAAGTAGCGATGAGATGATAAAGCGAATTACCGAAGACGGTTGGTATTTTGTAAAACAAAAAGGCTCTCACAA
GCACTACAAACACCCAACCAAAGAAGGTAAAGTAACAATCCCAAACGGTCGTGAAAACCTACCCAAAGGAACGCTAAAAA
GCATCATCAAACAAGCAGGGTTGGATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT184913 WP_001280954.1 NZ_CP066753:c3342199-3341825 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT184913 NZ_CP087840:c2250819-2250412 [Moraxella bovis]
ATGTTATTTCCCATTGCCATTGAAAAACCTGCCAATGAAAACGAATGTTATGGCGTGATTGTGCCAGACATTGCAGGGTG
TTTTAGTGCAGGCGATACACCTGATGAAGCCATTAAGAATGCTTATGAAGCCATCAGTTTGCATTTGGAAGGCATGGCAG
AAGATGGCGATACACTACCTACCGCCAAGCCCATTTTTTATCATCAAGACAATAGCGAATTTGACGGTATGTTGTGGGCA
GTGGTGGACGTGGATATGTCTGCCTTTATGGGTAAGGCGGAGAAAATCAACGTTACCTTGCCAAGCCTACTCATCACCAA
AATTGACGAAAAAGTCTTGTCTCATAAATCGCTATACAAAAGCCGTTCTAATTATTTGGCACAATTGGCGATGGCAGATT
TGGGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References