Detailed information of TA system TA184836

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 21328..21851
• Replicon: plasmid unnamed3
• Accession: NZ_CP066724
• Organism: Staphylococcus xylosus strain 2.1523

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: JGY88_RS14320
• Protein ID: WP_069828378.1
• Coordinates: 21585..21851 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: JGY88_RS14315
• Protein ID: WP_225486995.1
• Coordinates: 21328..21585 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JGY88_RS14280 (JGY88_14220)	16949..17779	+	831	WP_081324893.1	membrane protein insertase YidC	-
JGY88_RS14285 (JGY88_14225)	18029..18274	+	246	Protein_16	helix-turn-helix domain-containing protein	-
JGY88_RS14290 (JGY88_14230)	18778..18966	-	189	WP_225486991.1	hypothetical protein	-
JGY88_RS14295 (JGY88_14235)	19131..19736	+	606	WP_225486992.1	thioredoxin domain-containing protein	-
JGY88_RS14300 (JGY88_14240)	19783..20451	+	669	WP_225486993.1	hypothetical protein	-
JGY88_RS14305 (JGY88_14245)	20717..20809	-	93	WP_107389233.1	type I toxin-antitoxin system Fst family toxin	-
JGY88_RS14310 (JGY88_14250)	20883..21104	-	222	WP_225486994.1	hypothetical protein	-
JGY88_RS14315 (JGY88_14255)	21328..21585	+	258	WP_225486995.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JGY88_RS14320 (JGY88_14260)	21585..21851	+	267	WP_069828378.1	Txe/YoeB family addiction module toxin	Toxin
JGY88_RS14325 (JGY88_14265)	21973..22650	-	678	WP_069828379.1	hypothetical protein	-
JGY88_RS14330 (JGY88_14270)	22805..23200	-	396	WP_069828380.1	HTH domain-containing protein	-
JGY88_RS14335 (JGY88_14275)	23357..24511	-	1155	WP_225486996.1	SAP domain-containing protein	-
JGY88_RS14340 (JGY88_14280)	24522..24959	-	438	WP_069828382.1	hypothetical protein	-
JGY88_RS14345 (JGY88_14285)	25352..25732	+	381	WP_225486997.1	plasmid mobilization relaxosome protein MobC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..25872	25872

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (23-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10442.89 Da
• Isoelectric Point: 10.1982

>T184836 WP_069828378.1 NZ_CP066724:21585-21851 [Staphylococcus xylosus]
MGNYSVSIKNSAKSDLKKIKQSQLKTQFLKIVETLKEDPYFPNQSFEKLQPKHLGRYSRRINHQHRVVYTVDEDNKVVFI
TSAWSHYE

Nucleotide

• Length: 267 bp

>T184836 NZ_CP087817:c2677682-2677494 [Moraxella bovis]
ATGCCCCCAAGTAGCGATGAGATGATAAAGCGAATTACCGAAGACGGTTGGTATTTTGTAAAACAAAAAGGCTCTCACAA
GCACTACAAACACCCAACCAAAGAAGGTAAAGTAACAATCCCAAACGGTCGTGAAAACCTACCCAAAGGAACGCTAAAAA
GCATCATCAAACAAGCAGGGTTGGATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9777.83 Da
• Isoelectric Point: 4.6158

>AT184836 WP_225486995.1 NZ_CP066724:21328-21585 [Staphylococcus xylosus]
MNIKTPTNARKEFYELLKQVNDSHEPVIISGSKSENNAVIIGQKDWNSIQETLYLESTGTMDKVRKREKDSSGYTDINDL
DWDNI

Nucleotide

• Length: 258 bp

>AT184836 NZ_CP087817:c2677431-2677024 [Moraxella bovis]
ATGTTATTTCCCATTGCCATTGAAAAACCTGCCAATGAAAACGAATGTTATGGCGTGATTGTGCCAGACATTGCAGGGTG
TTTTAGTGCAGGCGATACACCTGATGAAGCCATTAAGAATGCTTATGAAGCCATCAGTTTGCATTTGGAAGGCATGGCAG
AAGATGGCGATACACTACCTACCGCCAAGCCCATTTTTTATCATCAAGACAATAGCGAATTTGACGGTATGTTGTGGGCA
GTGGTGGACGTGGATATGTCTGCCTTTATGGGTAAGGCGGAGAAAATCAACGTTACCTTGCCAAGCCTACTCATCACCAA
AATTGACGAAAAAGTCTTGTCTCATAAATCGCTATACAAAAGCCGTTCTAATTATTTGGCACAATTGGCGATGGCAGATT
TGGGGTAG