Detailed information of TA system TA184835

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 8139..8657
• Replicon: plasmid unnamed2
• Accession: NZ_CP066723
• Organism: Staphylococcus xylosus strain 2.1523

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: JGY88_RS13970
• Protein ID: WP_048794467.1
• Coordinates: 8139..8408 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: JGY88_RS13975
• Protein ID: WP_186330752.1
• Coordinates: 8409..8657 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JGY88_RS13930 (JGY88_13865)	3297..3596	+	300	Protein_3	IS6-like element IS257 family transposase	-
JGY88_RS13935 (JGY88_13870)	3765..4496	-	732	WP_186330849.1	ABC transporter permease	-
JGY88_RS13940 (JGY88_13875)	4496..5223	-	728	Protein_5	ABC transporter A subfamily ATP-binding protein	-
JGY88_RS13945 (JGY88_13880)	5220..5441	-	222	WP_107380614.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
JGY88_RS13950 (JGY88_13885)	5748..6251	-	504	WP_225486980.1	protein rep	-
JGY88_RS13955 (JGY88_13890)	6298..6972	-	675	WP_001105987.1	IS6-like element IS257 family transposase	-
JGY88_RS13960 (JGY88_13895)	7002..7571	-	570	WP_186330750.1	oxygen-insensitive NADPH nitroreductase	-
JGY88_RS13965 (JGY88_13900)	7702..8073	+	372	WP_186330751.1	helix-turn-helix domain-containing protein	-
JGY88_RS13970 (JGY88_13905)	8139..8408	-	270	WP_048794467.1	Txe/YoeB family addiction module toxin	Toxin
JGY88_RS13975 (JGY88_13910)	8409..8657	-	249	WP_186330752.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JGY88_RS13980 (JGY88_13915)	10125..10598	+	474	WP_225486981.1	hypothetical protein	-
JGY88_RS13985 (JGY88_13920)	10594..10902	+	309	Protein_14	recombinase family protein	-
JGY88_RS13990 (JGY88_13925)	10951..11838	+	888	WP_225486982.1	LysR family transcriptional regulator	-
JGY88_RS13995 (JGY88_13930)	11949..12473	+	525	WP_225486983.1	acyl-CoA thioesterase	-
JGY88_RS14000 (JGY88_13935)	12481..12855	+	375	WP_225486984.1	hypothetical protein	-
JGY88_RS14005 (JGY88_13940)	12989..13543	-	555	Protein_18	zinc-binding dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..51658	51658

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10377.84 Da
• Isoelectric Point: 9.9708

>T184835 WP_048794467.1 NZ_CP066723:c8408-8139 [Staphylococcus xylosus]
VAKLNITFSPQAFDDYEYFQTKDRKMVKRINQLLKSISRDGALDGIGKPEKLVGNFSGYYSRRINQEHRLVYTVNDNAIL
VASCRYHYK

Nucleotide

• Length: 270 bp

>T184835 NZ_CP087817:2631491-2631826 [Moraxella bovis]
ATGTTGCATTTTGCTGAAACATCATTATTCACTAAACAAATCATAGACTTAATGGATGATGACGAGTACAGACTATTACA
AACAAACTTGATGAAAAACCCACATCAAGGCGACATTGTTCGTGGTACTGGCGGAGTACGCAAAACAAGATGGTCAATTG
ATGGCAAGGGCAAAAGTGGTGGCAGTCGCATCATTTACTTTTTTGTTGATGGTGCTGGCATTTTCTTTATGCTCTTGGCT
TATCCTAAATCAAAACAAACAACGCTATCGGCGGATGAGAAAAAAGAAATGCTCAAACTAACCACCGCAATTAAGGAGAT
TTACCGTGCAAAATGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9502.63 Da
• Isoelectric Point: 4.5859

>AT184835 WP_186330752.1 NZ_CP066723:c8657-8409 [Staphylococcus xylosus]
MTVKSYSYVRENFKDMINKVNDDSDTITITTKDRNAVIMSEDNYNEIMETLYLQQNPANAKHLSESIENLERGNVKSKDI
LI

Nucleotide

• Length: 249 bp

>AT184835 NZ_CP087817:2631816-2632097 [Moraxella bovis]
GTGCAAAATGAGTTTTACGATGATTTAAAAGCCTCATTGACTGAGGCTCTGGCAATCGCTAAGGGCGAAATTTCCCCAAG
TCGTACATTCACTTATGAACGCCCAAACATCAAAGATATTCGGGCAAAAACAGGGCTATCACAAACCCAGTTCGCCCAGA
AGCTACACATAAGCCCTAAAACGCTTAAAAACTGGGAACAGGGCATTAGAACGCCAACAGGTCCAGCCATTACCCTAATT
AGATTACTTGACAAAAACCCTGATTTAATTAGCATGGCATAA