Detailed information of TA system TA184802

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 179317..179840
• Replicon: chromosome
• Accession: NZ_CP066713
• Organism: Staphylococcus pseudintermedius strain DSP026

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: JGZ50_RS00795
• Protein ID: WP_063278654.1
• Coordinates: 179574..179840 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A3D8YKM0
• Locus tag: JGZ50_RS00790
• Protein ID: WP_014612814.1
• Coordinates: 179317..179574 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JGZ50_RS00770	174656..174838	-	183	WP_096536006.1	hypothetical protein	-
JGZ50_RS00775	175365..176171	+	807	WP_199274813.1	arylamine N-acetyltransferase	-
JGZ50_RS00780	176465..176959	-	495	WP_015729749.1	membrane protein	-
JGZ50_RS00785	177219..179123	+	1905	WP_199274814.1	triacylglycerol lipase	-
JGZ50_RS00790	179317..179574	+	258	WP_014612814.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JGZ50_RS00795	179574..179840	+	267	WP_063278654.1	Txe/YoeB family addiction module toxin	Toxin
JGZ50_RS00800	180191..180292	-	102	WP_019169745.1	DUF2648 domain-containing protein	-
JGZ50_RS00805	180306..181799	-	1494	WP_014612817.1	malate dehydrogenase (quinone)	-
JGZ50_RS00810	182556..183323	+	768	WP_199274815.1	KxYKxGKxW signal peptide domain-containing protein	-
JGZ50_RS00815	184091..184600	-	510	WP_199274816.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (9-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10539.11 Da
• Isoelectric Point: 10.2281

>T184802 WP_063278654.1 NZ_CP066713:179574-179840 [Staphylococcus pseudintermedius]
MGNYSVLIKNSAKNDLKKIKKPLLKEQFSKIIEVLKINPYEASQSFEKLQPKHSARYSRRLNHQHRVVYTVDDEKREVYI
FSAWSHYE

Nucleotide

• Length: 267 bp

>T184802 NZ_CP087811:c100643-100308 [Moraxella bovis]
ATGTTGCATTTTGCTGAAACATCATTATTCACTAAACAAATCATAGACTTAATGGATGATGACGAGTACAGACTATTACA
AACAAACTTGATGAAAAACCCACATCAAGGCGACATTGTTCGTGGTACTGGCGGAGTACGCAAAACAAGATGGTCAATTG
ATGGCAAGGGCAAAAGTGGTGGCAGTCGCATCATTTACTTTTTTGTTGATGGTGCTGGCATTTTCTTTATGCTCTTGGCT
TATCCTAAATCAAAACAAACAACGCTATCGGCGGATGAGAAAAAAGAAATGCTCAAACTAACCACCGCAATTAAGGAGAT
TTACCGTGCAAAATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9866.87 Da
• Isoelectric Point: 4.1100

>AT184802 WP_014612814.1 NZ_CP066713:179317-179574 [Staphylococcus pseudintermedius]
MIIKTPTNARKEFYELLKQVNDNHEPIIISGSKSENNAVIVSQEDWDSIQETLFLEYTGTMDKVRAREKDDSGYTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT184802 NZ_CP087811:c100318-100037 [Moraxella bovis]
GTGCAAAATGAGTTTTACGATGATTTAAAAGCCTCATTGACTGAGGCTCTGGCAATCGCTAAGGGCGAAATTTCCCCAAG
TCGTACATTCACTTATGAACGCCCAAACATCAAAGATATTCGGGCAAAAACAGGGCTATCACAAACCCAGTTCGCCCAGA
AGCTACACATAAGCCCTAAAACGCTTAAAAACTGGGAACAGGGCATTAGAACGCCAACAGGTCCAGCCATTACCCTAATT
AGATTACTTGACAAAAACCCTGATTTAATTAGCATGGCATAA

Structures

Antitoxin

• AlphaFold DB: A0A3D8YKM0