Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 122382..122917 Replicon plasmid p1
Accession NZ_CP066660
Organism Enterococcus faecium strain Dallas 155

Toxin (Protein)


Gene name yoeB Uniprot ID Q3Y221
Locus tag JCP86_RS14655 Protein ID WP_002305108.1
Coordinates 122382..122654 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A133CED7
Locus tag JCP86_RS14660 Protein ID WP_002303154.1
Coordinates 122654..122917 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP86_RS14625 117388..118575 - 1188 WP_002303156.1 NADP-dependent malic enzyme -
JCP86_RS14630 118763..119710 + 948 WP_002303155.1 DNA-binding transcriptional regulator -
JCP86_RS14635 120007..120555 - 549 WP_002292681.1 hypothetical protein -
JCP86_RS14640 120556..121413 - 858 WP_002292680.1 AAA family ATPase -
JCP86_RS14645 121699..121986 - 288 WP_002300557.1 type II toxin-antitoxin system RelE/ParE family toxin -
JCP86_RS14650 121976..122305 - 330 WP_002292678.1 AbrB family transcriptional regulator -
JCP86_RS14655 122382..122654 - 273 WP_002305108.1 Txe/YoeB family addiction module toxin Toxin
JCP86_RS14660 122654..122917 - 264 WP_002303154.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JCP86_RS14665 123023..123439 - 417 WP_002303153.1 hypothetical protein -
JCP86_RS14670 123445..124008 - 564 Protein_130 IS6 family transposase -
JCP86_RS14675 124088..125250 + 1163 WP_086956687.1 IS3 family transposase -
JCP86_RS14680 125722..126621 - 900 WP_002303235.1 aldose 1-epimerase family protein -
JCP86_RS14685 126642..126914 - 273 WP_002305107.1 DUF3884 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(6')-aph(2'') - 1..187470 187470


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10806.28 Da        Isoelectric Point: 9.9080

>T184767 WP_002305108.1 NZ_CP066660:c122654-122382 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTYEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

>T184767 NZ_CP087803:c26231-26040 [Moraxella bovis]
ATGGCAAGCAGTAGAGAAGTCATTAAAATCATAAAAGCTGACGGTTGGTATCGTGTTAAATCAAATGGCGGTAGTCATCA
GCAATTCAAACACCCCACCAAAAAAGGTCGAGTTACTGTTCCCCACCCCAAAAAAGACTTAGCACAACCCACCATTGACA
GCATTATGAGACAAGCAGGGCTAAGCGATTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9886.16 Da        Isoelectric Point: 4.5370

>AT184767 WP_002303154.1 NZ_CP066660:c122917-122654 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDLKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp

>AT184767 NZ_CP087803:c26006-25602 [Moraxella bovis]
ATGTTATACCCCATTGCAATCTTAAAGGGCGATGATAAAACCGCCCACGGTATCTTTTTTCCCGATGTGCCAAATCTTGC
CAGTGCGTGCGATGACTTGCAAGACGTACACAAAATGGCACTAGAATGCCTTGATGTGCATTTTAGTGGCTTGGTAGAAG
ACGGCGAAGAAATCCCATTACCCACCAATTTTGACGCACACACCCAAAATAGCCAATTTGACGGCATGATGTGGGCGTGG
GTAGATGTGGACTTGTCAAAATATGACGTAAAAAGCCATAAAATCAACATTACCTTGCCTAACTATCTGATTGCCAAAAT
TGACGAAAAAGTCTTGTCTCATAAATCGCTATACAAAAGCCGTTCTAATTATTTGGCACAATTGGCGATGGCAGATTTGG
GGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133CER3

Antitoxin

Source ID Structure
AlphaFold DB A0A133CED7

References