184746

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 36562..37081 Replicon plasmid p3
Accession NZ_CP066625
Organism Enterococcus faecium strain Dallas 131_2

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag JCP79_RS15425 Protein ID WP_000588503.1
Coordinates 36824..37081 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag JCP79_RS15420 Protein ID WP_000388479.1
Coordinates 36562..36831 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP79_RS15395 32417..33300 + 884 Protein_36 SAM-dependent DNA methyltransferase -
JCP79_RS15400 33334..34014 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
JCP79_RS15405 34549..35229 - 681 WP_002287920.1 IS6-like element IS1216 family transposase -
JCP79_RS15410 35305..35871 + 567 Protein_39 hypothetical protein -
JCP79_RS15415 36252..36431 + 180 WP_001120991.1 hypothetical protein -
JCP79_RS15420 36562..36831 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JCP79_RS15425 36824..37081 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
JCP79_RS15430 37540..38544 + 1005 WP_000455809.1 hypothetical protein -
JCP79_RS15435 38709..39323 - 615 WP_001261742.1 recombinase family protein -
JCP79_RS15440 39773..41098 + 1326 WP_000969590.1 Y-family DNA polymerase -
JCP79_RS15445 41091..41441 + 351 WP_000568378.1 hypothetical protein -
JCP79_RS15450 41438..41617 + 180 WP_001021554.1 hypothetical protein -
JCP79_RS15455 41753..42043 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1..43860 43860


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T184746 WP_000588503.1 NZ_CP066625:36824-37081 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T184746 NZ_CP087798:c678207-677980 [Moraxella bovis]
ATCTCTGAGCGAGCAGGTTCACGCATGGCTGTGGCGCTAAACGGGCAAGTCATGGTTTTTCATCGCCCACACCCAAGCCC
AAATACTGACAAAAGTGCGGTTATGAGCATTAGAAAATGGCTTGATGGCATGGGTATCACACCATTAGATGACGACAGCC
AAACAGACGAATACGCAGACAAACAAACCGACGAACAGGAGCAGACTCATGAACACCATGACAATTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT184746 WP_000388479.1 NZ_CP066625:36562-36831 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT184746 NZ_CP087798:c677999-677664 [Moraxella bovis]
ATGAACACCATGACAATTAACAATCATAAAGCCTTAATCACTTTTGACAGTGAGTTAGGACTGTTTCGTGGGGAGTTTAT
CGGATTAAATGGCGGGGCAGATTTTTATGCTGACAGCGTAGATGGTCTCAATGAACAAGGGGCTTTATCCCTGCAAGCCT
TTTTAGATGTATGTCAAGAACAGGGCATTAGCCCTTATCAGTCGTACAGTGGCAAATTTGTCACACGCCTACCCAAAGAG
TTACATCAAAAAATCGCAGAAACTGCTACCGCCAAGGGTATTAGCCTAAACCAGTGGATTAATGAAACACTCAGCCGTGA
AGTTGGCTTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References