Detailed information of TA system TA184743

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 40727..40932
• Replicon: plasmid p2
• Accession: NZ_CP066624
• Organism: Enterococcus faecium strain Dallas 131_2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E3USR6
• Locus tag: JCP79_RS15110
• Protein ID: WP_002295624.1
• Coordinates: 40810..40932 (-)
• Length: 41 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	40727..40828 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JCP79_RS15080	35932..38136	+	2205	WP_025481008.1	type IA DNA topoisomerase	-
JCP79_RS15085	38152..38301	+	150	WP_002295632.1	hypothetical protein	-
JCP79_RS15090	38375..38968	+	594	WP_002287520.1	transcriptional regulator	-
JCP79_RS15095	38984..39883	+	900	WP_002305191.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
JCP79_RS15100	39886..40371	+	486	WP_002295626.1	single-stranded DNA-binding protein	-
JCP79_RS15105	40393..40650	+	258	WP_002305195.1	hypothetical protein	-
-	40727..40828	+	102	NuclAT_0	-	Antitoxin
JCP79_RS15110	40810..40932	-	123	WP_002295624.1	putative holin-like toxin	Toxin
JCP79_RS15115	41086..41346	+	261	WP_049055261.1	hypothetical protein	-
JCP79_RS15120	41789..41989	+	201	WP_002305199.1	hypothetical protein	-
JCP79_RS15125	41994..42431	+	438	WP_002287515.1	hypothetical protein	-
JCP79_RS15130	42424..43131	+	708	WP_002305202.1	hypothetical protein	-
JCP79_RS15135	43512..43691	+	180	WP_002305204.1	hypothetical protein	-
JCP79_RS15140	44297..44902	+	606	WP_002300095.1	Fic family protein	-
JCP79_RS15145	44918..45493	+	576	WP_002300096.1	recombinase family protein	-
JCP79_RS15150	45653..45856	+	204	WP_002300097.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..55497	55497

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (7-40)

Sequences

Toxin

Protein

• Length: 41 a.a.
• Molecular weight: 4431.42 Da
• Isoelectric Point: 10.3686

>T184743 WP_002295624.1 NZ_CP066624:c40932-40810 [Enterococcus faecium]
MKGVSLLSAYETIQTILGFGMFTIALISLIVNMLKNDKKK

Nucleotide

• Length: 123 bp

>T184743 NZ_CP087798:c100642-100307 [Moraxella bovis]
ATGTTGCATTTTGCTGAAACATCATTATTCACTAAACAAATCATAGACTTAATGGATGATGACGAGTACAGACTATTACA
AACAAACTTGATGAAAAACCCACATCAAGGCGACATTGTTCGTGGTACTGGCGGAGTACGCAAAACAAGATGGTCAATTG
ATGGCAAGGGCAAAAGTGGTGGCAGTCGCATCATTTACTTTTTTGTTGATGGTGCTGGCATTTTCTTTATGCTCTTGGCT
TATCCTAAATCAAAACAAACAACGCTATCGGCGGATGAGAAAAAAGAAATGCTCAAACTAACCACCGCAATTAAGGAGAT
TTACCGTGCAAAATGA

Antitoxin

Nucleotide

• Length: 102 bp

>AT184743 NZ_CP066624:40727-40828 [Enterococcus faecium]
CCCTCATTAACAGCACCGTTTAAAGAACGGCGGCTCAGATTAATTATTTATTGAGAAATAACCGATCCTCGCTAAAGTGA
CGGTTATTTCTTTTTGTCATTT

Structures

Toxin

• AlphaFold DB: E3USR6

Antitoxin