Detailed information of TA system TA184737

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 8316..8521
• Replicon: plasmid p124_3_59kb
• Accession: NZ_CP066616
• Organism: Enterococcus faecium strain Dallas 124_3

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E3USR6
• Locus tag: JCP92_RS14820
• Protein ID: WP_002295624.1
• Coordinates: 8316..8438 (+)
• Length: 41 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	8420..8521 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JCP92_RS14780	3392..3595	-	204	WP_002300097.1	hypothetical protein	-
JCP92_RS14785	3755..4330	-	576	WP_002300096.1	recombinase family protein	-
JCP92_RS14790	4346..4951	-	606	WP_002300095.1	Fic family protein	-
JCP92_RS14795	5557..5736	-	180	WP_002305204.1	hypothetical protein	-
JCP92_RS14800	6117..6824	-	708	WP_002305202.1	hypothetical protein	-
JCP92_RS14805	6817..7254	-	438	WP_002287515.1	hypothetical protein	-
JCP92_RS14810	7259..7459	-	201	WP_002305199.1	hypothetical protein	-
JCP92_RS14815	7902..8162	-	261	WP_049055261.1	hypothetical protein	-
JCP92_RS14820	8316..8438	+	123	WP_002295624.1	putative holin-like toxin	Toxin
-	8420..8521	-	102	NuclAT_0	-	Antitoxin
JCP92_RS14825	8598..8831	-	234	WP_046668935.1	hypothetical protein	-
JCP92_RS14830	8876..9361	-	486	WP_002295626.1	single-stranded DNA-binding protein	-
JCP92_RS14835	9364..10263	-	900	WP_002305191.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
JCP92_RS14840	10279..10872	-	594	WP_002287520.1	transcriptional regulator	-
JCP92_RS14845	10946..11095	-	150	WP_002295632.1	hypothetical protein	-
JCP92_RS14850	11111..13315	-	2205	WP_025481008.1	type IA DNA topoisomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..59583	59583

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (7-40)

Sequences

Toxin

Protein

• Length: 41 a.a.
• Molecular weight: 4431.42 Da
• Isoelectric Point: 10.3686

>T184737 WP_002295624.1 NZ_CP066616:8316-8438 [Enterococcus faecium]
MKGVSLLSAYETIQTILGFGMFTIALISLIVNMLKNDKKK

Nucleotide

• Length: 123 bp

>T184737 NZ_CP087796:1165428-1165670 [Moraxella bovis]
ATGAATTATAGCGAATTTCGCCAAAACCTAGCCTCTGCCCTTGATTATGTTCAAGACAGCCATGCCCCTGTGATTGTCAA
ACGTGGCAAACATTCTGCGGTGGTGATTAGTCTTGATGAATATAATGCTTTTAAAGAAACAGATTATCTATTGTCAAACC
CTGCTAATGCCGAACACCTTATGCGTGGCGTGCAAGCGGTAAAAAATCGTCAACTTACCCAAAGGGATTTGATTGAGGAT
TAG

Antitoxin

Nucleotide

• Length: 102 bp

>AT184737 NZ_CP066616:c8521-8420 [Enterococcus faecium]
CCCTCATTAACAGCACCGTTTAAAGAACGGCGGCTCAGATTAATTATTTATTGAGAAATAACCGATCCTCGCTAAAGTGA
CGGTTATTTCTTTTTGTCATTT

Structures

Toxin

• AlphaFold DB: E3USR6

Antitoxin