Detailed information of TA system TA184731

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1334..1539
• Replicon: plasmid p124_1_59kb
• Accession: NZ_CP066609
• Organism: Enterococcus faecium strain Dallas 124_1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E3USR6
• Locus tag: JCP68_RS14790
• Protein ID: WP_002295624.1
• Coordinates: 1417..1539 (-)
• Length: 41 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1334..1435 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JCP68_RS14780	494..979	+	486	WP_002295626.1	single-stranded DNA-binding protein	-
JCP68_RS14785	1024..1257	+	234	WP_046668935.1	hypothetical protein	-
-	1334..1435	+	102	NuclAT_0	-	Antitoxin
JCP68_RS14790	1417..1539	-	123	WP_002295624.1	putative holin-like toxin	Toxin
JCP68_RS14795	1693..1953	+	261	WP_049055261.1	hypothetical protein	-
JCP68_RS14800	2396..2596	+	201	WP_002305199.1	hypothetical protein	-
JCP68_RS14805	2601..3038	+	438	WP_002287515.1	hypothetical protein	-
JCP68_RS14810	3031..3738	+	708	WP_002305202.1	hypothetical protein	-
JCP68_RS14815	4119..4298	+	180	WP_002305204.1	hypothetical protein	-
JCP68_RS14820	4904..5509	+	606	WP_002300095.1	Fic family protein	-
JCP68_RS14825	5525..6100	+	576	WP_002300096.1	recombinase family protein	-
JCP68_RS14830	6260..6463	+	204	WP_002300097.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..59583	59583

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (7-40)

Sequences

Toxin

Protein

• Length: 41 a.a.
• Molecular weight: 4431.42 Da
• Isoelectric Point: 10.3686

>T184731 WP_002295624.1 NZ_CP066609:c1539-1417 [Enterococcus faecium]
MKGVSLLSAYETIQTILGFGMFTIALISLIVNMLKNDKKK

Nucleotide

• Length: 123 bp

>T184731 NZ_CP087793:c2284281-2283889 [Moraxella bovis]
ATGAAATATTTGCTGGACACCAATGCAGTCATTGCGATTTTGAATGCCAGTGAACGATTTTTGACCACGCTAGAACGGCA
TAAAGAGCGTGAAATTGCCATCTCGTCAATTGTTTTGTCGGAGCTGTATTATGGGGCGTACAAAAGCCAAAAAACCGCCC
AAAACCTTGAAAAAATCAATCTACTACCCTTTGAAGTGTTGCAATTTAATTCACAGGACGCTGATAAGGCTGGCGAAATT
GGTGCAACCCTAGAAAGGCGTGGCACACCCATTGGTTTTTATGACACGCTGATTGCAGGGCAAGCGATTGCCAATGATTT
GATTGTTATTACTGACAATGTGCGAGAATTTCTCCGAGTGGACGGTTTGCAAATTGAAAATTGGTTAAAATAA

Antitoxin

Nucleotide

• Length: 102 bp

>AT184731 NZ_CP066609:1334-1435 [Enterococcus faecium]
CCCTCATTAACAGCACCGTTTAAAGAACGGCGGCTCAGATTAATTATTTATTGAGAAATAACCGATCCTCGCTAAAGTGA
CGGTTATTTCTTTTTGTCATTT

Structures

Toxin

• AlphaFold DB: E3USR6

Antitoxin