184728

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 197488..198023 Replicon plasmid p111_212kb
Accession NZ_CP066600
Organism Enterococcus faecium strain Dallas 111

Toxin (Protein)


Gene name yoeB Uniprot ID R2PQC0
Locus tag JCP62_RS14875 Protein ID WP_002314366.1
Coordinates 197488..197760 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q3Y220
Locus tag JCP62_RS14880 Protein ID WP_002297422.1
Coordinates 197760..198023 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP62_RS14835 192593..193042 - 450 WP_010729386.1 TlpA family protein disulfide reductase -
JCP62_RS14840 193198..193740 - 543 WP_002298088.1 hypothetical protein -
JCP62_RS14845 194015..194658 + 644 Protein_213 transposase -
JCP62_RS14850 194734..195414 + 681 WP_002331383.1 IS6-like element IS1216 family transposase -
JCP62_RS14855 195473..195661 - 189 Protein_215 hypothetical protein -
JCP62_RS14860 195662..196519 - 858 WP_002292680.1 AAA family ATPase -
JCP62_RS14865 196805..197092 - 288 WP_002300557.1 type II toxin-antitoxin system RelE/ParE family toxin -
JCP62_RS14870 197082..197411 - 330 WP_002292678.1 AbrB family transcriptional regulator -
JCP62_RS14875 197488..197760 - 273 WP_002314366.1 Txe/YoeB family addiction module toxin Toxin
JCP62_RS14880 197760..198023 - 264 WP_002297422.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JCP62_RS14885 198260..198664 + 405 WP_002287522.1 IS200/IS605-like element ISEfa4 family transposase -
JCP62_RS14890 198681..199829 + 1149 WP_002287525.1 IS200/IS605 family element transposase accessory protein TnpB -
JCP62_RS14895 200148..201056 + 909 WP_002342382.1 IS982-like element ISEfm1 family transposase -
JCP62_RS14900 201059..202234 - 1176 WP_002336205.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..212766 212766
- inside IScluster/Tn - - 185924..210515 24591


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10780.24 Da        Isoelectric Point: 9.9724

>T184728 WP_002314366.1 NZ_CP066600:c197760-197488 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

>T184728 NZ_CP087793:1163738-1163995 [Moraxella bovis]
TTGAGGATTAGATGGTTTGATGAGGTATGGGAGGATTATTTGTATTGGCAAAGCCAAGATAAGAAAACCATAAAACGTAT
TAATACCTTGATTAAGGATTGCAGACGAGACCCTTTTGACGGTATCGGCAAACCCGAACCATTAAAATATAACCTAACAG
GCTACTGGTTAAGACGCATTGATGATGCCAACCGCTTGGTTTATTGTTGCGAAAGTGAAACACTCATCATTTCATGCCGT
CATCATTATGAGGCTTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9959.22 Da        Isoelectric Point: 4.5370

>AT184728 WP_002297422.1 NZ_CP066600:c198023-197760 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp

>AT184728 NZ_CP087793:1163506-1163748 [Moraxella bovis]
ATGAATTATAGCGAATTTCGCCAAAACCTAGCGTCCGCCCTTGATTATGTTCAAGACAGCCATGCCCCTGTGATTGTCAA
ACGTGGCAAACATTCTGCGGTGGTGATTAGTCTTGATGAATATAATGCTTTTAAAGAAACAGATTATCTATTGTCAAACC
CTGCTAATGCCGAACACCTTATGCGTGGCGTGCAAGCGGTAAAAAATCGTCAACTTACCCAAAGGGATTTGATTGAGGAT
TAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829F704

Antitoxin

Source ID Structure
AlphaFold DB A0A829F006

References