184724

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 33706..34225 Replicon plasmid p107_1_41kb
Accession NZ_CP066594
Organism Enterococcus faecium strain Dallas 107_1

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag JCQ02_RS15340 Protein ID WP_000588503.1
Coordinates 33968..34225 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag JCQ02_RS15335 Protein ID WP_000388479.1
Coordinates 33706..33975 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCQ02_RS15310 28978..30455 + 1478 Protein_33 type I restriction-modification system subunit M -
JCQ02_RS15315 30478..31158 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
JCQ02_RS15320 31693..32373 - 681 WP_002287920.1 IS6-like element IS1216 family transposase -
JCQ02_RS15325 32449..33015 + 567 Protein_36 hypothetical protein -
JCQ02_RS15330 33396..33575 + 180 WP_001120991.1 hypothetical protein -
JCQ02_RS15335 33706..33975 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JCQ02_RS15340 33968..34225 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
JCQ02_RS15345 34684..35688 + 1005 WP_000455809.1 hypothetical protein -
JCQ02_RS15350 35853..36467 - 615 WP_001261742.1 recombinase family protein -
JCQ02_RS15355 36917..38242 + 1326 WP_000969590.1 Y-family DNA polymerase -
JCQ02_RS15360 38235..38585 + 351 WP_000568378.1 hypothetical protein -
JCQ02_RS15365 38582..38761 + 180 WP_001021554.1 hypothetical protein -
JCQ02_RS15370 38897..39187 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1..41004 41004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T184724 WP_000588503.1 NZ_CP066594:33968-34225 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T184724 NZ_CP087793:739584-739919 [Moraxella bovis]
ATGTGCGAATTAATGTATGAATTAGAATTTGACGAGCGAGCCTTAAAAGAATGGCAAAAACTGGGCGACACCATAAAAAC
GCAGTTTAAAAAGAGACTGGCTAAGGTGCTAAAAAATCCGCACATCATCGCCAATCGCCTAAGCGGTGGACAAAATTTAT
ACAAAATCAACTTCCGCTCGGCAGGTTATCGCCTTGTGTATCAAGTTGAAGATGATAAAGTGGTGGTGTTTGTCATCGTG
ATGGGTAAGCGTGAGAAAAATGCCGTCTATGACACCGCCGAAGAATGGCTTGCTGAACGTCAATCGGACAATCAAGACAC
ACAATCTGTCAAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT184724 WP_000388479.1 NZ_CP066594:33706-33975 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT184724 NZ_CP087793:739342-739584 [Moraxella bovis]
ATGGCAAATATCGTGGCTCGTGTGGACGATGACCTAAAAGCCCAATCATTTTTGGTACTGCAAGAACTTGGCGTGACACC
GTCTGAGCTTATCCGCCAAACCTTGCAATATGTGGCTTATCACAAAAAATTACCCTTTAAGACGGTGGTTTTGACCGATG
AAGACAGTGAGCTTTTAGCCCTTGCCAAAGAACGCCTTGATAATCCTGCCCCACGCATCAAAGTCAGTTTGGACGAGCTT
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References