Detailed information of TA system TA184721

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 675..880
• Replicon: plasmid p107_1_55kb
• Accession: NZ_CP066593
• Organism: Enterococcus faecium strain Dallas 107_1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E3USR6
• Locus tag: JCQ02_RS14855
• Protein ID: WP_002295624.1
• Coordinates: 758..880 (-)
• Length: 41 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	675..776 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JCQ02_RS14850	341..598	+	258	WP_002305195.1	hypothetical protein	-
-	675..776	+	102	NuclAT_0	-	Antitoxin
JCQ02_RS14855	758..880	-	123	WP_002295624.1	putative holin-like toxin	Toxin
JCQ02_RS14860	1034..1294	+	261	WP_049055261.1	hypothetical protein	-
JCQ02_RS14865	1737..1937	+	201	WP_002305199.1	hypothetical protein	-
JCQ02_RS14870	1942..2379	+	438	WP_002287515.1	hypothetical protein	-
JCQ02_RS14875	2372..3079	+	708	WP_002305202.1	hypothetical protein	-
JCQ02_RS14880	3460..3639	+	180	WP_002305204.1	hypothetical protein	-
JCQ02_RS14885	4245..4850	+	606	WP_002300095.1	Fic family protein	-
JCQ02_RS14890	4866..5441	+	576	WP_002300096.1	recombinase family protein	-
JCQ02_RS14895	5601..5804	+	204	WP_002300097.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..55497	55497

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (7-40)

Sequences

Toxin

Protein

• Length: 41 a.a.
• Molecular weight: 4431.42 Da
• Isoelectric Point: 10.3686

>T184721 WP_002295624.1 NZ_CP066593:c880-758 [Enterococcus faecium]
MKGVSLLSAYETIQTILGFGMFTIALISLIVNMLKNDKKK

Nucleotide

• Length: 123 bp

>T184721 NZ_CP087791:c2253510-2253238 [Moraxella bovis]
GTGGCTAAACGTAGTTTTGAAATGGGCAATCCCTTTAAAAGGGATTTAAAAAAGCATTATTTGGCATTGATTGGCGAAGC
GTGGACGGAAGTGTCTGATTGCTTGTTAAATGCCAAACCCATACCTCAAAAATACCAAGACCACCCATTGCAAGGCGATT
GGGTGGGGTTTAGAGATTGTCATATCAAGCCTGATTTGGTGCTAATTTATAAAATAAATGATGAAGCGGTGGAATTACAT
CGGCTTGCCACGCATAGCGAGTTGTTTGGTTGA

Antitoxin

Nucleotide

• Length: 102 bp

>AT184721 NZ_CP066593:675-776 [Enterococcus faecium]
CCCTCATTAACAGCACCGTTTAAAGAACGGCGGCTCAGATTAATTATTTATTGAGAAATAACCGATCCTCGCTAAAGTGA
CGGTTATTTCTTTTTGTCATTT

Structures

Toxin

• AlphaFold DB: E3USR6

Antitoxin