Detailed information of TA system TA184716

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2807..3012
• Replicon: plasmid p103_56kb
• Accession: NZ_CP066587
• Organism: Enterococcus faecium strain Dallas 103

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E3USR6
• Locus tag: JCP83_RS15215
• Protein ID: WP_002295624.1
• Coordinates: 2890..3012 (-)
• Length: 41 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2807..2908 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JCP83_RS15190	232..381	+	150	WP_002295632.1	hypothetical protein	-
JCP83_RS15195	455..1048	+	594	WP_002287520.1	transcriptional regulator	-
JCP83_RS15200	1064..1963	+	900	WP_002305191.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
JCP83_RS15205	1966..2451	+	486	WP_002295626.1	single-stranded DNA-binding protein	-
JCP83_RS15210	2473..2730	+	258	WP_002305195.1	hypothetical protein	-
-	2807..2908	+	102	NuclAT_0	-	Antitoxin
JCP83_RS15215	2890..3012	-	123	WP_002295624.1	putative holin-like toxin	Toxin
JCP83_RS15220	3166..3426	+	261	WP_049055261.1	hypothetical protein	-
JCP83_RS15225	3869..4069	+	201	WP_002305199.1	hypothetical protein	-
JCP83_RS15230	4074..4511	+	438	WP_002287515.1	hypothetical protein	-
JCP83_RS15235	4504..5211	+	708	WP_002305202.1	hypothetical protein	-
JCP83_RS15240	5592..5771	+	180	WP_002305204.1	hypothetical protein	-
JCP83_RS15245	5953..7248	-	1296	WP_002297218.1	ISL3-like element ISEfa11 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..56588	56588
	-	flank	IS/Tn	-	-	5953..7248	1295

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (7-40)

Sequences

Toxin

Protein

• Length: 41 a.a.
• Molecular weight: 4431.42 Da
• Isoelectric Point: 10.3686

>T184716 WP_002295624.1 NZ_CP066587:c3012-2890 [Enterococcus faecium]
MKGVSLLSAYETIQTILGFGMFTIALISLIVNMLKNDKKK

Nucleotide

• Length: 123 bp

>T184716 NZ_CP087791:1314184-1314366 [Moraxella bovis]
ATGAAGTATTCAGAGTTTCAAAGGTGGCTATTGGCACAAGGGGCAACGGTAAACAAGCAAGGCGGTAAAGGCTCGCACCG
TAAAGTTACCCTAAATGGCAAAACCACCACTTTCCCTTATCACGGCAGTAAAGAGATTGGGGAAGGACTAAGAAAGAAAA
TTTTAAAAGACTTGGATTTATAG

Antitoxin

Nucleotide

• Length: 102 bp

>AT184716 NZ_CP066587:2807-2908 [Enterococcus faecium]
CCCTCATTAACAGCACCGTTTAAAGAACGGCGGCTCAGATTAATTATTTATTGAGAAATAACCGATCCTCGCTAAAGTGA
CGGTTATTTCTTTTTGTCATTT

Structures

Toxin

• AlphaFold DB: E3USR6

Antitoxin