Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 41499..42034 Replicon plasmid p97_1_201kb
Accession NZ_CP066569
Organism Enterococcus faecium strain Dallas 97_1

Toxin (Protein)


Gene name yoeB Uniprot ID Q3Y221
Locus tag JCP88_RS14330 Protein ID WP_002305108.1
Coordinates 41499..41771 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A133CED7
Locus tag JCP88_RS14335 Protein ID WP_002303154.1
Coordinates 41771..42034 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP88_RS14300 36505..37692 - 1188 WP_002303156.1 NADP-dependent malic enzyme -
JCP88_RS14305 37880..38827 + 948 WP_002303155.1 DNA-binding transcriptional regulator -
JCP88_RS14310 39124..39672 - 549 WP_002292681.1 hypothetical protein -
JCP88_RS14315 39673..40530 - 858 WP_002292680.1 AAA family ATPase -
JCP88_RS14320 40816..41103 - 288 WP_002300557.1 type II toxin-antitoxin system RelE/ParE family toxin -
JCP88_RS14325 41093..41422 - 330 WP_002292678.1 AbrB family transcriptional regulator -
JCP88_RS14330 41499..41771 - 273 WP_002305108.1 Txe/YoeB family addiction module toxin Toxin
JCP88_RS14335 41771..42034 - 264 WP_002303154.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JCP88_RS14340 42140..42556 - 417 WP_002303153.1 hypothetical protein -
JCP88_RS14345 42562..43125 - 564 Protein_48 IS6 family transposase -
JCP88_RS14350 43205..44367 + 1163 WP_086956687.1 IS3 family transposase -
JCP88_RS14355 44839..45738 - 900 WP_002303235.1 aldose 1-epimerase family protein -
JCP88_RS14360 45759..46031 - 273 WP_002305107.1 DUF3884 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(6')-aph(2'') - 1..201047 201047


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10806.28 Da        Isoelectric Point: 9.9080

>T184705 WP_002305108.1 NZ_CP066569:c41771-41499 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTYEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

>T184705 NZ_CP087784:c1574632-1574390 [Moraxella bovis]
ATGAATTATAGCGAATTTCGCCAAAACCTAGCGTCCGCCCTTGATTATGTTCAAGACAGCCATGCCCCTGTGATTGTCAA
ACGTGGCAAACATTCTGCGGTGGTGATTAGTCTTGATGAATATAATGCTTTTAAAGAAACAGATTATCTATTGTCAAACC
CTGCTAATGCCGAACACCTTATGCGTGGCGTGCAAGCGGTAAAAAATCGTCAACTTACCCAAAGGGATTTGATTGAGGAT
TAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9886.16 Da        Isoelectric Point: 4.5370

>AT184705 WP_002303154.1 NZ_CP066569:c42034-41771 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDLKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp

>AT184705 NZ_CP087784:c1574400-1574143 [Moraxella bovis]
TTGAGGATTAGATGGTTTGATGAGGTATGGGAGGATTATTTGTATTGGCAAAGCCAAGATAAGAAAACCATAAAACGTAT
TAATACCTTGATTAAGGATTGCAGACGAGACCCTTTTGACGGTATCGGCAAACCCGAACCATTAAAATATAACCTAACAG
GCTACTGGTTAAGACGCATTGATGATGCCAACCGCTTGGTTTATTGTTGCGAAAGTGAAACACTCATCATTTCATGCCGT
CATCATTATGAGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133CER3

Antitoxin

Source ID Structure
AlphaFold DB A0A133CED7

References