Detailed information of TA system TA184655

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1760819..1761479
• Replicon: chromosome
• Accession: NZ_CP066552
• Organism: Pectobacterium carotovorum strain 2A

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A221T809
• Locus tag: JFY74_RS07770
• Protein ID: WP_044203475.1
• Coordinates: 1760819..1761172 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: JFY74_RS07775
• Protein ID: WP_010298722.1
• Coordinates: 1761177..1761479 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFY74_RS07745	1756191..1756517	+	327	WP_198998638.1	hypothetical protein	-
JFY74_RS07750	1757347..1758318	+	972	WP_010298717.1	chemotaxis protein	-
JFY74_RS07755	1758434..1759273	-	840	WP_198998639.1	glutathione-dependent disulfide-bond oxidoreductase	-
JFY74_RS07760	1759438..1760049	-	612	WP_198998640.1	NAD(P)-dependent oxidoreductase	-
JFY74_RS07765	1760152..1760592	+	441	WP_010298720.1	helix-turn-helix transcriptional regulator	-
JFY74_RS07770	1760819..1761172	+	354	WP_044203475.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JFY74_RS07775	1761177..1761479	+	303	WP_010298722.1	XRE family transcriptional regulator	Antitoxin
JFY74_RS07780	1761516..1762520	-	1005	WP_198998641.1	threonine/serine dehydratase	-
JFY74_RS07785	1762573..1762911	+	339	WP_039473511.1	ArsR family transcriptional regulator	-
JFY74_RS07790	1762927..1763331	-	405	WP_198998642.1	helix-turn-helix transcriptional regulator	-
JFY74_RS07795	1763409..1763834	+	426	WP_198998643.1	DoxX family protein	-
JFY74_RS07800	1763954..1764589	+	636	WP_180776418.1	NAD(P)H-binding protein	-
JFY74_RS07805	1764809..1766008	-	1200	WP_198998644.1	multidrug effflux MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-81)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13609.59 Da
• Isoelectric Point: 9.8031

>T184655 WP_044203475.1 NZ_CP066552:1760819-1761172 [Pectobacterium carotovorum]
VWRIETTDVFDSWFSALNDRDRACVLAALIVLREKGPMLSRPYADTVKGSRYSNMKELRIQSRGTPIRAFFAFDPHRTGI
LLCAGNKSGNEKRFYDEMLPFAERELTNYLKKSEKRE

Nucleotide

• Length: 354 bp

>T184655 NZ_CP087765:c317435-317157 [Moraxella bovis]
ATGATTCAAAGTTTTAAGTGCAAAGATGCCCAAAGCCTGTTTGAAACAGGGTCAAGCCGTGTATTTGCCAACTTTTTATC
CGTTGCCACTCGCAAACTTACCATGCTTGATAATGCCGTGGCACTTGCCGACCTACGCATTCCACCTGCCAACCGCCTTG
AAAAGCTGACAGGCGATAGAGAAGGTCAGTATAGTATTCGCATTAACGACCAATTTCGCATTTGCTTTGTGTGGGGCGAT
GATGGCGTGTATGATGTTGAGATTGTTGATTATCACTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11282.16 Da
• Isoelectric Point: 5.6573

>AT184655 WP_010298722.1 NZ_CP066552:1761177-1761479 [Pectobacterium carotovorum]
MGRTLEQLLADEKPEVVVDAHAIATEMLLNIHLAELRERVQKTQVEMAQVLGLKQPTVAVMEKPGRDLKLSTLKRYVEAT
GSKLRLDVELPDGSHYEFML

Nucleotide

• Length: 303 bp

>AT184655 NZ_CP087765:c317127-316837 [Moraxella bovis]
ATGAGACCTGTTCACGCAGGTGAGGTATTGCGTGAAGAATATCTAATCCCAATGGGTATGTCCGCCACCGCCTTAGCAAA
TGCATTGGGCGTAACCCCTGCACGCATTAACGACATCGTGCGGCAGCGGCGTGGCGTTACGGCTGATACCGCTTTGCGTT
TGGCTCGTTATTTTGGCGGTACGGCACAATTTTGGCTAAACTTACAAACCACCTATGAGCTTCGCCTTGCCGAAACTACG
CTTGGCGACAGTTTGGATTTTATCAGCCCTCATGAAGTTGCCCATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A221T809