Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 613184..613686 Replicon chromosome
Accession NZ_CP066552
Organism Pectobacterium carotovorum strain 2A

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7T5UAW5
Locus tag JFY74_RS02765 Protein ID WP_039493889.1
Coordinates 613184..613438 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7W2E625
Locus tag JFY74_RS02770 Protein ID WP_039324900.1
Coordinates 613435..613686 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFY74_RS02745 608337..609599 - 1263 WP_180744549.1 L-rhamnose isomerase -
JFY74_RS02750 609596..611086 - 1491 WP_198998065.1 rhamnulokinase -
JFY74_RS02755 611423..612262 + 840 WP_039493893.1 HTH-type transcriptional activator RhaS -
JFY74_RS02760 612287..613141 + 855 WP_039507370.1 helix-turn-helix domain-containing protein -
JFY74_RS02765 613184..613438 - 255 WP_039493889.1 Txe/YoeB family addiction module toxin Toxin
JFY74_RS02770 613435..613686 - 252 WP_039324900.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JFY74_RS02775 613762..615468 - 1707 WP_198998066.1 ABC transporter ATP-binding protein -
JFY74_RS02780 615465..616331 - 867 WP_198998067.1 ABC transporter permease -
JFY74_RS02785 616324..617283 - 960 WP_039470517.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10228.81 Da        Isoelectric Point: 8.8560

>T184652 WP_039493889.1 NZ_CP066552:c613438-613184 [Pectobacterium carotovorum]
VKLIWSEEAWEDYLYWQDIDKRMVKKINELIKETRRTPFEGKGKPEPLKHNLAGFWSRRITEEHRLVYAITNDAMMIAAC
RYHY

Download         Length: 255 bp

>T184652 NZ_CP087763:982871-983176 [Lactobacillus gasseri]
ATGGCTCAAATTAACTACACTCCTCAATTTAAGCGAGATTATAAGAAGCTTAAAAGAAAACATTATGATTTGAATAAATT
AAAAAATGTCATTCAATTACTTATTGACGAAAAATTTAAAATTCTTGTTGATAAATATGATGACCATCAACTAAAAGGTT
CTTTAAGGTCACTACGTGCATTACATGTTGAGCATAATAAAGCTGGTAATTGGATTTTAGTTTATAAAATTCATAGCGGC
AATTTAGAACTGTTAACCATCGACTTGGTTTCTACTGGTTCCCACGATCATACTTATAGAACATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9367.64 Da        Isoelectric Point: 4.6119

>AT184652 WP_039324900.1 NZ_CP066552:c613686-613435 [Pectobacterium carotovorum]
MRTISYSEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAKRLMNSIESLKAGNGEERD
IIE

Download         Length: 252 bp

>AT184652 NZ_CP087763:982596-982871 [Lactobacillus gasseri]
ATGACAACTACCGTAAGTTTAAGATTACCAGAAGATTTAAAGAAACAAGCAACAGATGTATTCAACGAATACGGTCTCGA
TTGGTCATCTGCAATGCGAATGATCTTAACTCAAGTCGTAAGTGAAAATGCAATTCCTGTTAATTTACATAGATATTCTG
AAATTTCTCCTTCGATGAAATCAAATATTGATAGATCACTTCAAGAATACAAAGCAGGAAATTACAAAACCACAAACTCA
GTAAAAGAGCTATTTGAGGAGTTAGATAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T5UAW5

Antitoxin

Source ID Structure
AlphaFold DB A0A7W2E625

References