Detailed information of TA system TA184648

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA(toxin)
• Location: 102642..103993
• Replicon: chromosome
• Accession: NZ_CP066552
• Organism: Pectobacterium carotovorum strain 2A

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: JFY74_RS00450
• Protein ID: WP_198997804.1
• Coordinates: 102642..103682 (-)
• Length: 347 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: A0A7T5QPJ6
• Locus tag: JFY74_RS00455
• Protein ID: WP_039490249.1
• Coordinates: 103679..103993 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFY74_RS00420	98504..98893	+	390	WP_198997799.1	hypothetical protein	-
JFY74_RS00425	98966..99325	-	360	WP_198997800.1	hypothetical protein	-
JFY74_RS00430	99389..99991	-	603	WP_198997801.1	RhiA	-
JFY74_RS00435	100444..101349	+	906	WP_198997802.1	siderophore-interacting protein	-
JFY74_RS00440	101384..102139	-	756	WP_198997803.1	thiol:disulfide interchange protein DsbG	-
JFY74_RS00445	102264..102581	+	318	WP_198999012.1	LysE family transporter	-
JFY74_RS00450	102642..103682	-	1041	WP_198997804.1	HipA domain-containing protein	Toxin
JFY74_RS00455	103679..103993	-	315	WP_039490249.1	HipA N-terminal domain-containing protein	Antitoxin
JFY74_RS00460	103978..104304	-	327	WP_198997805.1	helix-turn-helix domain-containing protein	-
JFY74_RS00465	104491..105624	-	1134	WP_198997806.1	alkylhydroperoxidase domain protein	-
JFY74_RS00470	105621..106655	-	1035	WP_198997807.1	putative FMN-dependent luciferase-like monooxygenase	-
JFY74_RS00475	106657..108360	-	1704	WP_198997808.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (57-307)

Antitoxin

• HipA, N-terminal subdomain 1 (6-98)

Sequences

Toxin

Protein

• Length: 347 a.a.
• Molecular weight: 39578.53 Da
• Isoelectric Point: 6.2687

>T184648 WP_198997804.1 NZ_CP066552:c103682-102642 [Pectobacterium carotovorum]
MTTCRILLTPLTHEEEMATGYSRKGLKHLAGSMHTSPDLRFTRQQFMHDLPQTQKGMSISGYQPKIQMVLQDRAFIVVDH
QGLYILKPSPIEFPHLAENEHATMTLMARLGFAVPPHGLLRFKPEQADDEPEFAFVIKRFDRDEKTGHPIHQEQLDGAMG
IGEKFGKIRADGRQYVSYERLALFLSEHVNDNIVFKIDLFRRIAYAYMLGNNDMHLRNFGLIHSRSGQLMLSPIYDFVSV
APYPTYFSSCFMALPLLIQEEGDEALAPGFETADGEYLGMDFILFGQRIGLSEKLTKKLLADFIKEAECVESTYRDSFMP
AEAIDTTLRCYRHRLNLMSILDAERI

Nucleotide

• Length: 1041 bp

>T184648 NZ_CP087718:38647-38934 [Acinetobacter pittii]
ATGACCTATAAGTTAGACTTTTTAGAAGAAGCATTAGCAGAATGGAATAAGCTTAATCCAAGTATTAAGCAACCATTGAA
GAAGAAACTGATCAAGGTACTAGAGAATCCTCGCATTCCCAAGAATAAGCTCCCAGGACATCCTAACCGCTACAAGATCA
AACTTCGCAGTGTTGGTTATCGTTTGGTTTATGAAGTGATTGATGATGAGGTTATTTTCATCGTCATTGCCGTAGGCAGA
CGTGAAAACAATGCTGTGTATGATGAAGCCAACTCTCGACATTCATAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11850.72 Da
• Isoelectric Point: 9.7865

>AT184648 WP_039490249.1 NZ_CP066552:c103993-103679 [Pectobacterium carotovorum]
VRRQVKVYLYGVHIGQLSQDDKGYLFEYKKSYIGPPLSLSLPIQTGIFRSKTLPPYFASLAPEGWLRRQYSQLQHLDEKD
LFGILIQNGKNLIGAVQLIAEDKA

Nucleotide

• Length: 315 bp

>AT184648 NZ_CP087718:38409-38657 [Acinetobacter pittii]
ATGACTCAATTAATCCATGCACGAATGACTGCAAGTATTACTGAACTCAAAAAGAGTCCGATGGATACAGTGTTAGCAGG
TAAAGGTGAACCTGTAGCGATCCTTAATCGTAATATACCAGCGTTTTACTGTGTTCCGGCTGATTTGTATGAAACCATGA
TGGAACAACTGGAAGACCTGGAACTCAACAAAATTGCAGATGCTCGTGCGAATCAAAAACGCATTCGAGTAAATATTGAT
GACCTATAA

Structures

Antitoxin

• AlphaFold DB: A0A7T5QPJ6