Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 324718..325304 Replicon chromosome
Accession NZ_CP066528
Organism Klebsiella pneumoniae strain WCHKP090361

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag H3G66_RS01510 Protein ID WP_002920800.1
Coordinates 324936..325304 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0H3GZM4
Locus tag H3G66_RS01505 Protein ID WP_002920802.1
Coordinates 324718..324939 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3G66_RS01485 320875..321801 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
H3G66_RS01490 321798..323075 + 1278 WP_002920806.1 branched chain amino acid ABC transporter permease LivM -
H3G66_RS01495 323072..323839 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
H3G66_RS01500 323841..324554 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
H3G66_RS01505 324718..324939 + 222 WP_002920802.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H3G66_RS01510 324936..325304 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
H3G66_RS01515 325577..326893 + 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
H3G66_RS01520 327000..327887 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
H3G66_RS01525 327884..328729 + 846 WP_002920789.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
H3G66_RS01530 328731..329801 + 1071 WP_002920787.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 321798..330538 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T184559 WP_002920800.1 NZ_CP066528:324936-325304 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T184559 NZ_CP087686:8620-8943 [Xylella taiwanensis]
ATGACTCAACGCGGCGACCTTGTAACGGTTTCCCTGCAAGGCGATTATGGCAAACCTAGACCGGCGTTAATCCTCCAATC
AGACCTGCTGATGGAGCTAGATAGTGTCGTACTGTGTCCGGTCACAAGTGAGCTACGTAATGCGATATTTCGCATCACCG
TTGAACCAAACATAGCCAATGGGCTACGGACGCTCTCGCAAATCATGGTAGACAAAATTTCAACACTGCCGCGTAGCAAA
ATCAGCAAACCTTTTGGACATCTCAATGACGAGAGGATAAAAGCAGTAGAAAAAGCACTGTTGCTCATCGTTGGTATCAT
CTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8181.18 Da        Isoelectric Point: 4.7769

>AT184559 WP_002920802.1 NZ_CP066528:324718-324939 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT184559 NZ_CP087686:8402-8623 [Xylella taiwanensis]
ATGGCATTCATTCACGAACCGACTAGCAAAGTAGCTCGCCACCGAAAGCAAATGCGCGCAGCGGGATTACGTCCTGTCCA
GTTCTGGGTACCGGATACGCGCACACCGGAATTCGCCGCTGAAATTCGGAGCCAGTGCAGGAGCCTGAAGAACGACCCGG
AAGAAGCTGACGCTTTGCGCTTCACCGAAGAAGCCATAACCCATATTGAAGGCTGGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZM4

References