Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 355152..355798 Replicon chromosome
Accession NZ_CP066523
Organism Klebsiella pneumoniae strain WCHKP090357

Toxin (Protein)


Gene name higB Uniprot ID W8UNE1
Locus tag H3G71_RS01635 Protein ID WP_002920560.1
Coordinates 355152..355499 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag H3G71_RS01640 Protein ID WP_002920557.1
Coordinates 355499..355798 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3G71_RS01625 351078..352511 + 1434 WP_002920564.1 glycogen synthase GlgA -
H3G71_RS01630 352529..354976 + 2448 WP_002920561.1 glycogen phosphorylase -
H3G71_RS01635 355152..355499 + 348 WP_002920560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H3G71_RS01640 355499..355798 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
H3G71_RS01645 355861..357369 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
H3G71_RS01650 357574..357903 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
H3G71_RS01655 357954..358784 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
H3G71_RS01660 358834..359592 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13502.56 Da        Isoelectric Point: 6.2300

>T184532 WP_002920560.1 NZ_CP066523:355152-355499 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRACFAFDPLRKAI
VLCVGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T184532 NZ_CP087680:c713-309 [Xylella taiwanensis]
TTGCTCGATACGAACATCATTAGCGACATGATCCGTAATCCGTTTGGACTAGTTGCGTGTCGCATTGAAAAGGTCGATCC
AAAAGAGGTTTGCACTAGCATCGTTGTCGCTGCTGAGTTGCGGTATGGTTGTGCAAAGAAAGGATCGACCAAGTTGCTTG
CGAAGGTGAAGCTCATGCTTGAAACAATTCCTGTGCTGCCTTTGGATATTCCTACCGACGCTGAATATGGTCGCATTCGT
GCAGAGTTGGAGTCAGTAGGACAAACTATCGGCTTAAATGATCTATTGATAGGTACTCATGCTTATGTACTGGGGATGAC
ATTGGTAACGGATAATGTTAAAGAGTTTAAGCGTATTCGTGGCCTTAAGATCGAAAATTGGCTGGAATGTGCATCCTCGG
TTTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT184532 WP_002920557.1 NZ_CP066523:355499-355798 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT184532 NZ_CP087680:c994-722 [Xylella taiwanensis]
ATGTCTATTTCTATGCCATCATCTAGACTCAAGGAAGCTAAGCTGTTCCGCAACAATCGCAGTCAGGCCGTGAGAATTCC
GGTTGAGTTTGAATTACCGGGGGATCGAGTATTGATTCATCGCGAGGGTAGCAAGCTCATCATTGAGCCTGTGAGCATGC
CTACCAACATTATAGAATTGTTAGCGCAGTGGAAAACGGAAGATCCGCTTGGACTTGAAGATCAGTTTCCTGAAATTGAG
GACATGCTTGCTAAGCCGGATGACATATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CBY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References