Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 736099..736874 | Replicon | chromosome |
Accession | NZ_CP066517 | ||
Organism | Klebsiella pneumoniae strain WCHKP090329 |
Toxin (Protein)
Gene name | TacT2 | Uniprot ID | A0A1Q4Q548 |
Locus tag | H3G99_RS03675 | Protein ID | WP_004150910.1 |
Coordinates | 736389..736874 (+) | Length | 162 a.a. |
Antitoxin (Protein)
Gene name | TacA2 | Uniprot ID | W8UEW1 |
Locus tag | H3G99_RS03670 | Protein ID | WP_004150912.1 |
Coordinates | 736099..736392 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H3G99_RS03650 | 731307..731909 | - | 603 | WP_062954968.1 | short chain dehydrogenase | - |
H3G99_RS03655 | 732007..732918 | + | 912 | WP_004188550.1 | LysR family transcriptional regulator | - |
H3G99_RS03660 | 732919..734067 | - | 1149 | WP_004150915.1 | PLP-dependent aspartate aminotransferase family protein | - |
H3G99_RS03665 | 734078..735454 | - | 1377 | WP_004217775.1 | cystathionine beta-synthase | - |
H3G99_RS03670 | 736099..736392 | + | 294 | WP_004150912.1 | DUF1778 domain-containing protein | Antitoxin |
H3G99_RS03675 | 736389..736874 | + | 486 | WP_004150910.1 | GNAT family N-acetyltransferase | Toxin |
H3G99_RS03680 | 737578..738171 | + | 594 | WP_004188553.1 | hypothetical protein | - |
H3G99_RS03685 | 738268..738484 | + | 217 | Protein_724 | transposase | - |
H3G99_RS03690 | 739090..739962 | + | 873 | WP_004188557.1 | ParA family protein | - |
H3G99_RS03695 | 739962..740345 | + | 384 | WP_004150906.1 | hypothetical protein | - |
H3G99_RS03700 | 740338..741705 | + | 1368 | WP_004150905.1 | replicative DNA helicase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
flank | IS/Tn | - | - | 738268..738420 | 152 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17551.59 Da Isoelectric Point: 8.8818
>T184502 WP_004150910.1 NZ_CP066517:736389-736874 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A
Download Length: 486 bp
>T184502 NZ_CP087674:c1605147-1604965 [Pseudomonas aeruginosa]
ATGAAGTTCAGCGAATTCAGACGATGGTTGAAGGCCCAAGGGGTGACCTTCGAAGCCGGCAAGGGAAGCCACTTCAAGAT
CACCGCCCCGAACGGCAAACAGACCACCTTCGCGGACCACGGAACTAAGGAAATGCCAGAACCGACCCGCAAGGCGATCA
TCAAGCAACTGGGGCTCAAATGA
ATGAAGTTCAGCGAATTCAGACGATGGTTGAAGGCCCAAGGGGTGACCTTCGAAGCCGGCAAGGGAAGCCACTTCAAGAT
CACCGCCCCGAACGGCAAACAGACCACCTTCGCGGACCACGGAACTAAGGAAATGCCAGAACCGACCCGCAAGGCGATCA
TCAAGCAACTGGGGCTCAAATGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10901.46 Da Isoelectric Point: 6.3783
>AT184502 WP_004150912.1 NZ_CP066517:736099-736392 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE
Download Length: 294 bp
>AT184502 NZ_CP087674:c1604918-1604436 [Pseudomonas aeruginosa]
ATGTACGACTATGCAATCCGTTTCGAACAGGACGATAGCGCTCCTGGCGTCGCCGTTTTCTGCAGAGACCTGCCGGAACT
GAACAGCTACGGTGACGATAAGGCCCATGCAATCAGCGAGGCGGTTGACGCCATCGAGTCAACCCTCTCGCTGTACGTTG
ATCAGCGCCGAGAAATCCCCGCAGCCAGCCAGGCGCAACCAGGCGAGCGCGTGATCCATCTGCCGGCGGTTACAGTTGCG
AAGATCGCGCTCTGGAACGAAATGGTCCGGCGAGATATGCGAAAGGCCGACCTCTGCAGGCTGCTCGGTATCGCACAAAC
TCAGGGCGACAGGCTCGTTGACTTCCTCCACAACACCAAAATGGAAGCGCTGGAAAATGCGCTTGATTTTCTCGGCCTTC
GGCTGCGAGTTCAGATCGAGCGGGACAAAGACGTAGAGCGAAAAATGGCGGAACCGCCGGAGCGTGGAAAGCTCAGGGCC
TGA
ATGTACGACTATGCAATCCGTTTCGAACAGGACGATAGCGCTCCTGGCGTCGCCGTTTTCTGCAGAGACCTGCCGGAACT
GAACAGCTACGGTGACGATAAGGCCCATGCAATCAGCGAGGCGGTTGACGCCATCGAGTCAACCCTCTCGCTGTACGTTG
ATCAGCGCCGAGAAATCCCCGCAGCCAGCCAGGCGCAACCAGGCGAGCGCGTGATCCATCTGCCGGCGGTTACAGTTGCG
AAGATCGCGCTCTGGAACGAAATGGTCCGGCGAGATATGCGAAAGGCCGACCTCTGCAGGCTGCTCGGTATCGCACAAAC
TCAGGGCGACAGGCTCGTTGACTTCCTCCACAACACCAAAATGGAAGCGCTGGAAAATGCGCTTGATTTTCTCGGCCTTC
GGCTGCGAGTTCAGATCGAGCGGGACAAAGACGTAGAGCGAAAAATGGCGGAACCGCCGGAGCGTGGAAAGCTCAGGGCC
TGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1Q4Q548 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GVL4 |