Detailed information of TA system TA184497

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2512232..2512755
• Replicon: chromosome
• Accession: NZ_CP066492
• Organism: Staphylococcus aureus strain nan_175_F371_ch

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: JF380_RS12635
• Protein ID: WP_000074046.1
• Coordinates: 2512232..2512498 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2K4AGF2
• Locus tag: JF380_RS12640
• Protein ID: WP_000587615.1
• Coordinates: 2512498..2512755 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JF380_RS12615	2507631..2508815	-	1185	WP_198914129.1	MFS transporter	-
JF380_RS12620	2509167..2509940	-	774	WP_000072148.1	iron export ABC transporter permease subunit FetB	-
JF380_RS12625	2509933..2510595	-	663	WP_000923528.1	ATP-binding cassette domain-containing protein	-
JF380_RS12630	2510843..2511919	-	1077	WP_001076667.1	M42 family metallopeptidase	-
JF380_RS12635	2512232..2512498	-	267	WP_000074046.1	Txe/YoeB family addiction module toxin	Toxin
JF380_RS12640	2512498..2512755	-	258	WP_000587615.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JF380_RS12645	2513113..2513577	+	465	WP_000736689.1	DUF1307 domain-containing protein	-
JF380_RS12650	2513727..2515304	-	1578	WP_000143490.1	FMN-binding glutamate synthase family protein	-
JF380_RS12655	2515494..2516243	+	750	WP_000019956.1	hypothetical protein	-
JF380_RS12660	2516467..2517660	-	1194	WP_000675403.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10658.27 Da
• Isoelectric Point: 10.1384

>T184497 WP_000074046.1 NZ_CP066492:c2512498-2512232 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKPFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T184497 NZ_CP087673:c2074739-2074557 [Pseudomonas aeruginosa]
ATGAAGTTCAGCGAATTCAGACGATGGTTGAAGGCCCAAGGGGTGACCTTCGAAGCCGGCAAAGGAAGCCACTTCAAGAT
CACCGCCCCGAACGGCAAACAGACCACCTTCGCGGACCACGGAGCTAAGGAAATGCCAGAACCGACCCGCAAGGCGATCA
TCAAGCAACTGGGGCTCAAATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9746.68 Da
• Isoelectric Point: 4.1111

>AT184497 WP_000587615.1 NZ_CP066492:c2512755-2512498 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLDDWKSIQETIYLESTGTMDKVRDREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT184497 NZ_CP087673:c2074510-2074082 [Pseudomonas aeruginosa]
ATGTACGACTATGCAATCCGTTTCGAACAGGACGATAGCACTCCTGGCGTTGCCGTTTTCTGCCGAGACCTACCGGAGCT
GAACAGCTATGGCGACGACAAGGCCCACGCAATCGGCGAGGCAGTCGACGCCATCGAGTCGACCCTCTCGCTGTACGTTG
ATCAGCGCCGAGAAATCCCCGCAGCCAGCCAGGCACAACCAGGCGAGCGCGTTATCCATCTGCCGGCAGTTACCGTTGCG
AAGATCGCGCTCTGGAACGAAATGGTTCGTCGAGATATGCGAAAGGCTGACCTCTGCCGGCTCCTCGGTATCGCACAAAC
CCAGGGCGACAGGCTCGTCGACTTCCTCCACAACACCAAGATGGAAGCCATGGAGAACGCGCTATCCGCCCTCGGCCTCC
GCCTCTCAGTGAATATTGAGGCGGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A2K4AGF2