Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2455965..2456482 Replicon chromosome
Accession NZ_CP066492
Organism Staphylococcus aureus strain nan_175_F371_ch

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag JF380_RS12370 Protein ID WP_000113262.1
Coordinates 2455965..2456231 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag JF380_RS12375 Protein ID WP_000584499.1
Coordinates 2456231..2456482 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JF380_RS12340 2451391..2451927 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
JF380_RS12345 2452160..2452984 - 825 WP_000572040.1 formate/nitrite transporter family protein -
JF380_RS12350 2453201..2453383 - 183 WP_000230294.1 hypothetical protein -
JF380_RS12355 2453467..2453934 - 468 WP_000153344.1 SRPBCC domain-containing protein -
JF380_RS12360 2454120..2455670 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
JF380_RS12365 2455859..2455930 - 72 Protein_2391 hypothetical protein -
JF380_RS12370 2455965..2456231 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
JF380_RS12375 2456231..2456482 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JF380_RS12380 2456647..2456748 - 102 WP_001791744.1 hypothetical protein -
JF380_RS12385 2456755..2457354 - 600 WP_000162813.1 DsbA family protein -
JF380_RS12390 2457373..2457735 - 363 WP_198914124.1 DUF4467 domain-containing protein -
JF380_RS12395 2457990..2459240 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
JF380_RS12400 2459337..2460068 - 732 WP_000615470.1 amino acid ABC transporter ATP-binding protein -
JF380_RS12405 2460065..2460784 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T184494 WP_000113262.1 NZ_CP066492:c2456231-2455965 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T184494 NZ_CP087672:26785-27090 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT184494 WP_000584499.1 NZ_CP066492:c2456482-2456231 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT184494 NZ_CP087672:26565-26783 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References